USP51 antibody

Catalog No. ABIN6265932

Product Details anti-USP51 Antibody

Target: USP51 (Ubiquitin Specific Peptidase 51 (USP51))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This USP51 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Specificity: USP51 Antibody detects endogenous levels of total USP51

Cross-Reactivity: Human, Mouse (Murine), Rat (Rattus)

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human USP51

Isotype: IgG

Application Details

Application Notes: WB 1:1000-3000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C.Stable for 12 months from date of receipt

Expiry Date: 12 months

Target Details for USP51

Target: USP51 (Ubiquitin Specific Peptidase 51 (USP51))

Alternative Name: USP51 (USP51 Products)

Synonyms: AV136873 antibody, ubiquitin specific peptidase 51 antibody, ubiquitin specific protease 51 antibody, USP51 antibody, Usp51 antibody

Background:

Description: Specifically deubiquitinates 'Lys-14' (H2AK13Ub) and 'Lys-16'(H2AK15Ub) of histone H2A regulating the DNA damage response at double-strand breaks (DSBs) (PubMed:27083998). USP51 is recruited to chromatin after DNA damage and regulates the dynamic assembly/disassembly of TP53BP1 and BRCA1. Exhibits also activity for 'Lys-27' or 'Lys-63'-linked di-ubiquitin (PubMed:27083998).

Gene: USP51

Molecular Weight: 80 kDa

Gene ID: 158880

UniProt: Q70EK9