VAMP8 antibody (Internal Region)
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- Target See all VAMP8 Antibodies
- VAMP8 (Vesicle-Associated Membrane Protein 8 (Endobrevin) (VAMP8))
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Binding Specificity
- Internal Region
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This VAMP8 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA
- Specificity
- VAMP8 Antibody detects endogenous levels of total VAMP8.
- Predicted Reactivity
- Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Xenopus
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human VAMP8, corresponding to a region within the internal amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product VAMP8 Primary Antibody
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- Application Notes
- WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20 °C. Stable for 12 months from date of receipt.
- Expiry Date
- 12 months
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- Target
- VAMP8 (Vesicle-Associated Membrane Protein 8 (Endobrevin) (VAMP8))
- Alternative Name
- VAMP8 (VAMP8 Products)
- Synonyms
- vamp8 antibody, EDB antibody, VAMP-8 antibody, AU041171 antibody, Edb antibody, endobrevin antibody, wu:fa18d07 antibody, zgc:56588 antibody, vesicle associated membrane protein 8 antibody, vesicle-associated membrane protein 8 (endobrevin) antibody, vesicle-associated membrane protein 8 antibody, vamp8 antibody, VAMP8 antibody, Vamp8 antibody
- Background
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Description: SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. VAMP8 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane via its interaction with the STX17-SNAP29 binary t-SNARE complex (PubMed:23217709, PubMed:25686604). Also required for dense-granule secretion in platelets (PubMed:12130530). Plays also a role in regulated enzyme secretion in pancreatic acinar cells (By similarity). Involved in the abscission of the midbody during cell division, which leads to completely separate daughter cells (By similarity). Involved in the homotypic fusion of early and late endosomes (By similarity).
Gene: VAMP8
- Molecular Weight
- 15 kDa
- Gene ID
- 8673
- UniProt
- Q9BV40
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