WNT7A antibody (Internal Region)

Catalog No. ABIN6266046

Product Details anti-WNT7A Antibody

Target: WNT7A (Wingless-Type MMTV Integration Site Family, Member 7A (WNT7A))

Binding Specificity: Internal Region

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This WNT7A antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Specificity: Wnt7a Antibody detects endogenous levels of total Wnt7a.

Predicted Reactivity: Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human Wnt7a, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for WNT7A

Target: WNT7A (Wingless-Type MMTV Integration Site Family, Member 7A (WNT7A))

Alternative Name: WNT7A (WNT7A Products)

Synonyms: wnt7a antibody, AI849442 antibody, Wnt-7a antibody, px antibody, tw antibody, Xwnt-7a antibody, wnt-7a antibody, wnt7a-A antibody, Wnt family member 7A antibody, wingless-type MMTV integration site family, member 7Aa antibody, wingless-type MMTV integration site family, member 7A antibody, wingless-type MMTV integration site family member 7A S homeolog antibody, WNT7A antibody, wnt7aa antibody, Wnt7a antibody, wnt7a.S antibody

Background:

Description: Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt/beta-catenin signaling pathway (By similarity). Plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development (PubMed:16826533). Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes. Required for normal neural stem cell proliferation in the hippocampus dentate gyrus. Required for normal progress through the cell cycle in neural progenitor cells, for self-renewal of neural stem cells, and for normal neuronal differentiation and maturation. Promotes formation of synapses via its interaction with FZD5 (By similarity).

Gene: WNT7A

Molecular Weight: 39kDa

Gene ID: 7476

UniProt: O00755

Pathways: WNT Signaling, Stem Cell Maintenance, Asymmetric Protein Localization