Kv2.1/KCNB1 antibody (AA 510-590)

Catalog No. ABIN6284347

Product Details anti-Kv2.1/KCNB1 Antibody

Target: Kv2.1/KCNB1 (KCNB1) (Potassium Voltage-Gated Channel, Shab-Related Subfamily, Member 1 (KCNB1))

Binding Specificity: AA 510-590

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Kv2.1/KCNB1 antibody is un-conjugated

Application: ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purpose: Kv2.1 is a protein encoded by the KCNB1 gene which is approximately 95,8 kDa. Kv2.1 is localised to the cell membrane. It is involved in integration of energy metabolism, potassium channels and aquaporin-mediated transport. It contributes to the regulation of the action potential (AP) repolarization, duration and frequency of repetitive AP firing in neurons, muscle cells and endocrine cells and also plays a role in homeostatic attenuation of electrical excitability throughout the brain. Kv2.1 is expressed in the brain, heart, lung, liver, colon, kidney and adrenal gland. Mutations in the KCNB1 gene may result in epileptic encephalopathy. STJ93873 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Kv2.1 protein.

Specificity: Kv2.1 Polyclonal Antibody detects endogenous levels of Kv2.1 protein.

Characteristics: Rabbit polyclonal to Kv2.1.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from human Kv2.1 around the non-phosphorylation site of S567.

Isotype: IgG

Application Details

Application Notes: IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:20000

Comment:

Expressed in neocortical pyramidal cells . Expressed in pancreatic beta cells (at protein level) . Expressed in brain, heart, lung, liver, colon, kidney and adrenal gland . Expressed in the cortex, amygdala, cerebellum, pons, thalamus, hypothalamus, hippocampus and substantia nigra .

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C, and avoid repeat freeze-thaw cycles.

Target Details for Kv2.1/KCNB1

Target: Kv2.1/KCNB1 (KCNB1) (Potassium Voltage-Gated Channel, Shab-Related Subfamily, Member 1 (KCNB1))

Alternative Name: Kv2.1 (KCNB1 Products)

Synonyms: KCNB1 antibody, Kcnb1 antibody, Kcr1-1 antibody, Kv2.1 antibody, Shab antibody, DRK1PC antibody, DRK1 antibody, KV2.1 antibody, h-DRK1 antibody, potassium voltage-gated channel subfamily B member 1 antibody, potassium voltage-gated channel, Shab-related subfamily, member 1 antibody, potassium channel, voltage gated Shab related subfamily B, member 1 antibody, potassium voltage gated channel, Shab-related subfamily, member 1 antibody, KCNB1 antibody, kcnb1 antibody, LOC100541632 antibody, Kcnb1 antibody

Molecular Weight: 90 kDa

Gene ID: 3745

UniProt: Q14721

Pathways: Synaptic Membrane