PHLDA2 antibody

Catalog No. ABIN6292224

Product Details anti-PHLDA2 Antibody

Target: PHLDA2 (Pleckstrin Homology-Like Domain, Family A, Member 2 (PHLDA2))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PHLDA2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Purification: Affinity purification

Immunogen: Recombinant protein of human PHLDA2

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000
IHC 1:50 - 1:200

Comment:

Expressed in placenta and adult prostate gland, In placenta, it is present in all cells of the villous cytotrophoblast, The protein is absent in cells from hydatidiform moles, Hydatidiform mole is a gestation characterized by abnormal development of both fetus and trophoblast, The majority of hydatidiform moles are associated with an excess of paternal to maternal genomes and are likely to result from the abnormal expression of imprinted genes (at protein level), Expressed at low levels in adult liver and lung, and fetal liver, Expressed in adult brain and neuroblastoma, medullablastoma and glioblastoma cell lines

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20C. Avoid freeze / thaw cycles.

Target Details for PHLDA2

Target: PHLDA2 (Pleckstrin Homology-Like Domain, Family A, Member 2 (PHLDA2))

Alternative Name: PHLDA2 (PHLDA2 Products)

Synonyms: PHLDA2 antibody, ipl antibody, phlda2 antibody, BRW1C antibody, BWR1C antibody, HLDA2 antibody, IPL antibody, TSSC3 antibody, Ipl antibody, Tssc3 antibody, zgc:110459 antibody, pleckstrin homology like domain family A member 2 antibody, Pleckstrin homology-like domain family A member 2 antibody, pleckstrin homology like domain, family A, member 2 antibody, pleckstrin homology-like domain, family A, member 2 antibody, pleckstrin homology-like domain, family A, member 2 L homeolog antibody, PHLDA2 antibody, phla2 antibody, Phlda2 antibody, phlda2.L antibody, phlda2 antibody

Background: This gene is located in a cluster of imprinted genes on chromosome 11p15.5, which is considered to be an important tumor suppressor gene region. Alterations in this region may be associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene has been shown to be imprinted, with preferential expression from the maternal allele in placenta and liver.

Molecular Weight: 17.092 kDa

Gene ID: 7262

UniProt: Q53GA4

Pathways: Regulation of Carbohydrate Metabolic Process