ITGB3BP antibody

Catalog No. ABIN6293028

Product Details anti-ITGB3BP Antibody

Target: ITGB3BP (Integrin beta 3 Binding Protein (Beta3-Endonexin) (ITGB3BP))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ITGB3BP antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Purification: Affinity purification

Immunogen: Recombinant protein of human ITGB3BP

Isotype: IgG

Application Details

Application Notes: IHC 1:50 - 1:200

Comment:

Widely expressed, Expressed in spleen, thymus, prostate, ovary, small intestine and white blood cells, Highly expressed in testis and colon, Isoform 4 is expressed in platelets, lymphocytes and granulocytes

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20C. Avoid freeze / thaw cycles.

Target Details for ITGB3BP

Target: ITGB3BP (Integrin beta 3 Binding Protein (Beta3-Endonexin) (ITGB3BP))

Alternative Name: ITGB3BP (ITGB3BP Products)

Synonyms: CENP-R antibody, CENPR antibody, HSU37139 antibody, NRIF3 antibody, TAP20 antibody, 4930471O16Rik antibody, AU022583 antibody, integrin subunit beta 3 binding protein antibody, integrin beta 3 binding protein (beta3-endonexin) antibody, ITGB3BP antibody, Itgb3bp antibody

Background: This gene encodes a transcriptional coregulator that binds to and enhances the activity of members of the nuclear receptor families, thyroid hormone receptors and retinoid X receptors. This protein also acts as a corepressor of NF-kappaB-dependent signaling. This protein induces apoptosis in breast cancer cells through a caspase 2-mediated signaling pathway. This protein is also a component of the centromere-specific histone H3 variant nucleosome associated complex (CENP-NAC) and may be involved in mitotic progression by recruiting the histone H3 variant CENP-A to the centromere. Alternate splicing results in multiple transcript variants.

Molecular Weight: 20.194 kDa

Gene ID: 23421

UniProt: Q13352

Pathways: Neurotrophin Signaling Pathway