MAP3K1 antibody (AA 1211-1310)

Catalog No. ABIN6294295

This Mouse Monoclonal antibody specifically detects MAP3K1 in IHC. It exhibits reactivity toward Human.

Quick Overview for MAP3K1 antibody (AA 1211-1310) (ABIN6294295)

Target: MAP3K1 (Mitogen-Activated Protein Kinase Kinase Kinase 1 (MAP3K1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This MAP3K1 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Product Details anti-MAP3K1 Antibody

Binding Specificity: AA 1211-1310

Purpose: Mouse anti-Human MAP3K1 Antibody [IHC only]

Specificity: Cytoplasmic

Purification: A partial recombinant protein (aa 1211-1310) was used as the immunogen for the MAP3K1 antibody.

Immunogen: A partial recombinant protein (aa 1211-1310) was used as the immunogen for the MAP3K1 antibody.

Application Details

Application Notes: Prediluted format : incubate for 30 min at RT (2)

Restrictions: For Research Use only

Handling

Buffer: Prediluted in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide, For IHC use only

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Target Details for MAP3K1

Target: MAP3K1 (Mitogen-Activated Protein Kinase Kinase Kinase 1 (MAP3K1))

Alternative Name: Mitogen-activated protein kinase kinase kinase 1

Background:

Target Description: Mitogen-activated protein (MAP) kinase cascades are activated by various extracellular stimuli, including growth factors. The MEK kinases (also designated MAP kinase kinase kinases, MKKKs, MAP3Ks or MEKKs) phosphorylate and thereby activate the MEKs (also called MAP kinase kinases or MKKs), including ERK, JNK and p38. These activated MEKs in turn phosphorylate and activate the MAP kinases. The MEK kinases include Raf-1, Raf-B, Mos, MEK kinase-1, MEK kinase-2, MEK kinase-3, MEK kinase-4 and ASK 1 (MEK kinase- 5). MEK kinase-1 activates the ERK and c-Jun NH2-terminal kinase (JNK) pathways by phosphorylation of MAP2K1 and MAP2K4, and also activates the central protein kinases of the NF-kB pathway, CHUK and IKBKB. Additionally, MEK kinase-1 uses an E3 ligase through its PHD domain, a RING-finger-like structure, to target proteins for degradation through ubiquitination.

Gene Symbol: MAP3K1///MAPKKK1///MEKK///MEKK1

Gene ID: 4214

UniProt: Q13233

Pathways: MAPK Signaling, Interferon-gamma Pathway, Caspase Cascade in Apoptosis, TLR Signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Regulation of Actin Filament Polymerization, Toll-Like Receptors Cascades