MAP3K1 antibody (pThr1402)

Catalog No. ABIN7138774

The Rabbit Polyclonal anti-MAP3K1 antibody (ABIN7138774) specifically detects MAP3K1 in WB, ELISA and IHC. The antibody is reactive with Human samples.

Quick Overview for MAP3K1 antibody (pThr1402) (ABIN7138774)

Target: MAP3K1 (Mitogen-Activated Protein Kinase Kinase Kinase 1 (MAP3K1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAP3K1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-MAP3K1 Antibody

Binding Specificity: pThr1402

Purpose: Phospho-MAP3K1 (Thr1402) Antibody

Cross-Reactivity: Mouse, Rat

Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogen: Peptide sequence around phosphorylation site of threonine 1402(T-G-A(p)-G-F) derived from Human MAP3K1.

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for MAP3K1

Target: MAP3K1 (Mitogen-Activated Protein Kinase Kinase Kinase 1 (MAP3K1))

Alternative Name: MAP3K1

Background:

Background:

Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway.

Schmutz J., Nature 431:268-274(2004).
Xia Y., Genes Dev. 12:3369-3381(1998).
Vinik B.S., Mamm. Genome 6:782-783(1995)

Aliases: M3K1_HUMAN antibody, MAP3K1 antibody, MAPK/ERK kinase kinase 1 antibody, MAPKKK1 antibody, MEK kinase 1 antibody, MEKK 1 antibody, Mekk antibody, MEKK1 antibody, Mitogen activated protein kinase kinase kinase 1 antibody, Mitogen activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase antibody, Mitogen-activated protein kinase kinase kinase 1 antibody, SRXY6 antibody

UniProt: Q13233

Pathways: MAPK Signaling, Interferon-gamma Pathway, Caspase Cascade in Apoptosis, TLR Signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Regulation of Actin Filament Polymerization, Toll-Like Receptors Cascades