TGFB1 antibody

Catalog No. ABIN6296206

This Mouse Monoclonal antibody specifically detects TGFB1 in Func and Neut. It exhibits reactivity toward Human, Rat, Mouse, Cow, Dog, Monkey and Hamster.

Quick Overview for TGFB1 antibody (ABIN6296206)

Target: TGFB1 (Transforming Growth Factor, beta 1 (TGFB1))

Reactivity: Human, Rat, Mouse, Cow, Dog, Monkey, Hamster

Host: Mouse

Clonality: Monoclonal

Conjugate: This TGFB1 antibody is un-conjugated

Application: Functional Studies (Func), Neutralization (Neut)

Product Details anti-TGFB1 Antibody

Purpose: Mouse anti-Human/Monkey/Cow/Dog/Mouse/Rat/Hamster TGF-beta Antibody [Sodium Azide Free]

Specificity: Cytoplasm and extracellular (secreted)

Purification: Bovine TGF-beta2 protein was used as the immunogen for the TGF-beta antibody.

Immunogen: Bovine TGF-beta2 protein was used as the immunogen for the TGF-beta antibody.

Application Details

Application Notes: Functional Activity: Cytokine Neutralization (Order SAF formulation)

Restrictions: For Research Use only

Handling

Buffer: In 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Target Details for TGFB1

Target: TGFB1 (Transforming Growth Factor, beta 1 (TGFB1))

Alternative Name: Transforming growth factor beta-1 ]

Background:

Target Description: This mAb recognizes TGF beta 1, 2 and 3. Three TGFbs have been identified in mammals. TGFb1, TGFb2 and TGFb3 are each synthesized as precursor proteins that are very similar in that each is cleaved to yield a 112 amino acid polypeptide that remains associated with the latent portion of the molecules. Biologically active TGFb requires dimerization of the monomers (usually homodimers) and release of the latent peptide portion. Overall, the mature region of the TGFb3 protein has approximately 80 % identity to the mature region of both TGFb1 and TGFb2. However, the NH2 terminals or precursor regions of their molecules share only 27 % sequence identity. TGFb's inhibit the growth of epithelial cells and stimulate the growth of mesenchymal cells.

Gene Symbol: TGFB1///TGFB///TGFB3///TGFB2

UniProt: P01137, P10600, P61812

Pathways: EGFR Signaling Pathway, Dopaminergic Neurogenesis, Cellular Response to Molecule of Bacterial Origin, Glycosaminoglycan Metabolic Process, Regulation of Leukocyte Mediated Immunity, Regulation of Muscle Cell Differentiation, Positive Regulation of Immune Effector Process, Cell-Cell Junction Organization, Production of Molecular Mediator of Immune Response, Ribonucleoside Biosynthetic Process, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process, Protein targeting to Nucleus, Autophagy, Cancer Immune Checkpoints