CDKN1C antibody

Catalog No. ABIN6297439

This Mouse Monoclonal antibody specifically detects CDKN1C in IHC. It exhibits reactivity toward Human and Mouse.

Quick Overview for CDKN1C antibody (ABIN6297439)

Target: CDKN1C (Cyclin-Dependent Kinase Inhibitor 1C (p57, Kip2) (CDKN1C))

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This CDKN1C antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Product Details anti-CDKN1C Antibody

Purpose: Mouse anti-Human/Mouse p57 Antibody [IHC only]

Specificity: Nuclear

Purification: Recombinant human protein was used as the immunogen for the p57 antibody.

Immunogen: Recombinant human protein was used as the immunogen for the p57 antibody.

Application Details

Application Notes: Prediluted format : incubate for 30 min at RT (2)

Restrictions: For Research Use only

Handling

Buffer: Prediluted in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide, For IHC use only

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Target Details for CDKN1C

Target: CDKN1C (Cyclin-Dependent Kinase Inhibitor 1C (p57, Kip2) (CDKN1C))

Alternative Name: Cyclin-dependent kinase inhibitor 1C

Background:

Target Description: Recognizes a protein of 57 kDa, identified as p57Kip2. It shows no cross-reaction with p27Kip1. p57Kip2 is a potent tight-binding inhibitor of several G1 cyclin complexes, and is a negative regulator of cell proliferation. Anti-p57 has been used as an aide in identification of complete hydatidiform mole (CHM) (no nuclear labeling of cytotrophoblasts and stromal cells) from partial hydatidiform mole (PHM) in which both cytotrophoblasts and stromal cells stain. The histological differentiation of complete mole, partial mole, and hydropic spontaneous abortion is problematic. Most complete hydatidiform moles are diploid, whereas most partial moles are triploid. Ploidy studies will identify partial moles, but will not differentiate complete moles from non-molar gestations. Complete moles carry a high risk of persistent disease and choriocarcinoma, while partial moles have a very low risk. In normal placenta, many cytotrophoblast nuclei and stromal cells are labeled with this antibody. Similar findings apply to PHM and hydropic abortus tissues. Intervillous trophoblastic islands (IVTIs) demonstrate nuclear labeling in all three entities and serve as an internal control.

Gene Symbol: CDKN1C///KIP2

Gene ID: 1028

UniProt: P49918

Pathways: Cell Division Cycle, Dopaminergic Neurogenesis