TYMS antibody

Catalog No. ABIN6297576

This anti-TYMS antibody is a Mouse Monoclonal antibody detecting TYMS in IHC. Suitable for Human.

Quick Overview for TYMS antibody (ABIN6297576)

Target: TYMS (Thymidylate Synthetase (TYMS))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TYMS antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Product Details anti-TYMS Antibody

Purpose: Mouse anti-Human Thymidylate Synthase Antibody [IHC only]

Specificity: Cytoplasmic

Purification: Recombinant human Thymidylate synthase was used as the immunogen for this antibody.

Immunogen: Recombinant human Thymidylate synthase was used as the immunogen for this antibody.

Application Details

Application Notes: Prediluted format : incubate for 30 min at RT (2)

Restrictions: For Research Use only

Handling

Buffer: Prediluted in 1X PBS ( pH 7.4) with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide, For IHC use only

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Target Details for TYMS

Target: TYMS (Thymidylate Synthetase (TYMS))

Alternative Name: Thymidylate synthase

Background:

Target Description: This antibody is specific for a protein of 36 kDa, identified as Thymidylate Synthase (TS). Thymidylate synthase converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. Thymidylate synthase is also a critical target for the fluoropyrimidines, an important group of anti-neoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates thymidylate synthase by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of thymidylate synthase protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.

Gene Symbol: TYMS///TS///OK///SW-cl.29

Gene ID: 7298

UniProt: P04818

Pathways: Mitotic G1-G1/S Phases