RNMT antibody

Catalog No. ABIN6297752

The Mouse Monoclonal anti-RNMT antibody has been validated for IHC. It is suitable to detect RNMT in samples from Human, Rat, Cow and Dog.

Quick Overview for RNMT antibody (ABIN6297752)

Target: RNMT (RNA Guanine-7 Methyltransferase (RNMT))

Reactivity: Human, Rat, Cow, Dog

Host: Mouse

Clonality: Monoclonal

Conjugate: This RNMT antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Product Details anti-RNMT Antibody

Purpose: Mouse anti-Human/Cow/Dog/Rat TAG-72 Antibody Cocktail [IHC only]

Specificity: Cytoplasmic and cell surface

Purification: The membrane-enriched fraction of a human breast carcinoma liver metastasis (B72.3) and TAG-72 protein (CA72/733) were used as the immunogens for this antibody cocktail.

Immunogen: The membrane-enriched fraction of a human breast carcinoma liver metastasis (B72.3) and TAG-72 protein (CA72/733) were used as the immunogens for this antibody cocktail.

Application Details

Application Notes: Prediluted format : incubate for 30 min at RT (2)

Restrictions: For Research Use only

Handling

Buffer: Prediluted in 1X PBS ( pH 7.4) with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide, For IHC use only

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Target Details for RNMT

Target: RNMT (RNA Guanine-7 Methyltransferase (RNMT))

Alternative Name: mRNA cap guanine-N7 methyltransferase  

Background:

Target Description: This antibody recognizes an oncofetal antigen of 220 kDa, identified as a tumor-associated glycoprotein (TAG-72) with properties of a mucin. This antibody defines the mucin-carried sialylated-Tn epitope. TAG-72 is usually expressed by adenocarcinomas, but is negative in mesotheliomas. Studies have reported that this antibody has 80 % sensitivity and 93 % specificity for pulmonary adenocarcinoma. Therefore, TAG-72 is a useful marker to distinguish between mesothelioma and adenocarcinoma. However, false positive reactions can occur so results must be interpreted with the utmost caution. This antibody may be useful in the differentiation of non-small cell carcinomas from small cell carcinomas of the lung. The combined use of TAG-72 antibody with a GCDFP-15 antibody is valuable in the diagnosis of apocrine carcinoma.

Gene Symbol: tag-72  C25A1.3

Gene ID: 182875

UniProt: Q9XVS1