PLVAP antibody

Catalog No. ABIN642822

Product Details anti-PLVAP Antibody

Target: PLVAP (Plasmalemma Vesicle Associated Protein (PLVAP))

Reactivity: Mouse

Host: Rat

Conjugate: This PLVAP antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro))

Specificity: DS-MB-03957 recognizes murine plasmalemma vesicle-associated protein (PLVAP), a 60kD protein which is otherwise known as MECA-32 and PV-1. PLVAP is a transmembrane homodimer which is associated with endothelial cell caveolae and fenestrae. In adult and embryonic mice, PLVAP is primarily expressed on endothelial tissues but shows restricted distribution in the skeletal, cardiac and brain tissues. In embryonic mice, PLVAP expression, on the vasculature associated with blood brain barrier has been reported to be developmentally regulated. In humans, PLVAP is selectively up-regulated in a variety of high-grade brain tumors, including glioblastoma and metastatic carcinoma, as well as other cerebral disorders associated with blood-brain barrier disruption, such as acute ischemia. PLVAP represents a novel marker of brain tumor angiogenesis and integrity of the blood-brain barrier and is a potential therapeutic target.

Characteristics: Rat Anti-Mouse PLVAP

Purification: Purified

Isotype: IgG2a

Application Details

Restrictions: For Research Use only

Handling

Concentration: IgG concentration 1.0 mg/ml

Buffer: Phosphate buffered saline, pH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Target Details for PLVAP

Target: PLVAP (Plasmalemma Vesicle Associated Protein (PLVAP))

Alternative Name: PLVAP (PLVAP Products)

Synonyms: MECA32 antibody, Pv1 antibody, FELS antibody, PV-1 antibody, PV1 antibody, gp68 antibody, plasmalemma vesicle associated protein antibody, Plvap antibody, PLVAP antibody