ERBB3 antibody

Catalog No. ABIN645836

The Goat not_set anti-ERBB3 antibody is suitable to detect ERBB3 in samples from Mouse and Rat.

Quick Overview for ERBB3 antibody (ABIN645836)

Target: ERBB3 (Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3))

Reactivity: Mouse, Rat

Host: Goat

Conjugate: This ERBB3 antibody is un-conjugated

Application: Please inquire

Product Details anti-ERBB3 Antibody

Specificity: The ErbB3 goat antibody detects protein derived from human, Jurkat cell lysate at various concentrations.

Cross-Reactivity: Mouse (Murine), Rat (Rattus)

Characteristics: Goat Anti-ERBB3 / HER3

Immunogen: Peptide with sequence -HSRLFPKANAQRT, from the C-terminus of the protein sequence according to NP_001973.2. was used as immunogen.

Isotype: IgG

Application Details

Restrictions: For Research Use only

Handling

Reconstitution: Supplied as 100 µg of purified antibody. 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Please avoid freeze-thaw cycles.

Storage: -20 °C

Target Details for ERBB3

Target: ERBB3 (Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3))

Alternative Name: ERBB3 / HER3

Background: The EGF receptor family comprises several related receptor tyrosine kinases that are frequently overexpressed in a variety of carcinomas. Members of this receptor family include EGFR (HER1), Neu (ErbB-2, HER2), ErbB-3 (HER3) and ErbB-4 (HER4), which form either homodimers or heterodimers upon ligand binding. Full length ErbB-3 is detected at 180 kDa by SDS-PAGE and is overexpressed in human mammary tumors. The ErbB-3 gene also produces several alternative variants, including a secreted form of 85 kDa which negatively regulates heregulin-stimulated ErbB activation. ErbB-3 heterodimerizes with Neu and binds heregulin in order to activate phosphoinositide (PI) 3-kinase. The recruitment and activation of PI 3-kinase occurs via its interaction with phosphorylated YXXM motifs in the carboxy terminus of ErbB-3.

NCBI Accession: NP_001973

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway