HAS1 antibody (AA 166-193)

Catalog No. ABIN651121

This Rabbit Polyclonal antibody specifically detects HAS1 in WB. It exhibits reactivity toward Humanand has been mentioned in 1 publication.

Quick Overview for HAS1 antibody (AA 166-193) (ABIN651121)

Target: HAS1 (Hyaluronan Synthase 1 (HAS1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HAS1 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB24040

Product Details anti-HAS1 Antibody

Binding Specificity: AA 166-193

Predicted Reactivity: M

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This HAS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 166-193 amino acids from the Central region of human HAS1.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-HAS1 antibody (ABIN651121)

Raheem, Marei, Mifsud, Khalid, Wathes, Fouladi-Nashta: "Regulation of the hyaluronan system in ovine endometrium by ovarian steroids." in: Reproduction (Cambridge, England), Vol. 145, Issue 5, pp. 491-504, (2013) (PubMed).

Target Details for HAS1

Target: HAS1 (Hyaluronan Synthase 1 (HAS1))

Alternative Name: HAS1

Background: Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS1 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to the hasA gene product of Streptococcus pyogenes, a glycosaminoglycan synthetase (DG42) from Xenopus laevis, and a recently described murine hyaluronan synthase.

Molecular Weight: 64832

Gene ID: 3036

NCBI Accession: NP_001514

UniProt: Q92839

Pathways: Glycosaminoglycan Metabolic Process