PINK1 antibody (C-Term)

Catalog No. ABIN652208

There is 1 publication for this product available. The Rabbit Polyclonal anti-PINK1 antibody is suitable to detect PINK1 in samples from Human and Mouse. It has been validated for WB.

Quick Overview for PINK1 antibody (C-Term) (ABIN652208)

Target: PINK1 (PTEN Induced Putative Kinase 1 (PINK1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PINK1 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB6517

Product Details anti-PINK1 Antibody

Binding Specificity: AA 493-526, C-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This Park6(PINK1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 493-526 amino acids from the C-terminal region of human Park6(PINK1).

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-PINK1 antibody (ABIN652208)

Berthier, Jiménez-Sáinz, Pulido: "PINK1 regulates histone H3 trimethylation and gene expression by interaction with the polycomb protein EED/WAIT1." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 110, Issue 36, pp. 14729-34, (2013) (PubMed).

Target Details for PINK1

Target: PINK1 (PTEN Induced Putative Kinase 1 (PINK1))

Alternative Name: Park6 (PINK1)

Background: Parkinson is the second most common neurodegenerative disease after Alzheimers. About 1 percent of people over the age of 65 and 3 percent of people over the age of 75 are affected by the disease. The mutation is the most common cause of Parkinson disease identified to date. Defects in PINK1 are the cause of autosomal recessive early-onset Parkinson's disease 6 (PARK6). Six novel pathogenic PINK1 mutations suggest that PINK1 may be the second most common causative gene next to parkin in parkinsonism with the recessive mode of inheritance. Strong evidence indicates that, although important in mendelian forms of Parkinson's disease (PD), PINK1 does not influence the cause of sporadic nonmendelian forms of PD.

Molecular Weight: 62769

Gene ID: 65018

NCBI Accession: NP_115785

UniProt: Q9BXM7

Pathways: Autophagy