INSIG1 antibody (N-Term)

Catalog No. ABIN652887

This anti-INSIG1 antibody is a Rabbit Polyclonal antibody detecting INSIG1 in WB, FACS and IHC (p). Suitable for Human.

Quick Overview for INSIG1 antibody (N-Term) (ABIN652887)

Target: INSIG1 (Insulin Induced Gene 1 (INSIG1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This INSIG1 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB21689

Product Details anti-INSIG1 Antibody

Binding Specificity: AA 36-63, N-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This INSIG1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 36-63 amino acids from the N-terminal region of human INSIG1.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:50~100. FC: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

Target Details for INSIG1

Target: INSIG1 (Insulin Induced Gene 1 (INSIG1))

Alternative Name: INSIG1

Background: INSIG1 is an insulin-induced protein. This protein encodes an endoplasmic reticulum (ER) membrane protein that plays a critical role in regulating cholesterol concentrations in cells. This protein binds to the sterol-sensing domains of SREBP cleavage-activating protein (SCAP) and HMG CoA reductase, and is essential for the sterol-mediated trafficking of the two proteins.

Molecular Weight: 29987

Gene ID: 3638

NCBI Accession: NP_005533, NP_938150, NP_938151

UniProt: O15503

Pathways: ER-Nucleus Signaling