FBXW12 antibody (C-Term)

Catalog No. ABIN654226

Product Details anti-FBXW12 Antibody

Target: FBXW12 (F-Box and WD Repeat Domain Containing 12 (FBXW12))

Binding Specificity: AA 291-320, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FBXW12 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This FBXW12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 291-320 amino acids from the C-terminal region of human FBXW12.

Clone: RB27619

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:50~100. FC: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

Target Details for FBXW12

Target: FBXW12 (F-Box and WD Repeat Domain Containing 12 (FBXW12))

Alternative Name: FBXW12 (FBXW12 Products)

Synonyms: FBW12 antibody, FBXO12 antibody, FBXO35 antibody, RGD1307859 antibody, F-box and WD repeat domain containing 12 antibody, FBXW12 antibody, Fbxw12 antibody

Background: Members of the F-box protein family, such as FBXW12, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1, MIM 603034), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM].

Gene ID: 285231

NCBI Accession: NP_001153399, NP_001153401, NP_996985

UniProt: Q6X9E4