CD11b antibody (N-Term)

Catalog No. ABIN654625

This Rabbit Polyclonal antibody specifically detects CD11b in FACS, WB and IHC (p). It exhibits reactivity toward Humanand has been mentioned in 1 publication.

Quick Overview for CD11b antibody (N-Term) (ABIN654625)

Target: CD11b (ITGAM) (Integrin alpha M (ITGAM))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CD11b antibody is un-conjugated

Application: Flow Cytometry (FACS), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB17991

Product Details anti-CD11b Antibody

Binding Specificity: AA 253-282, N-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This CD11b antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 253-282 amino acids from the N-terminal region of human CD11b.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:2000. WB: 1:1000. WB: 1:500. IHC-P: 1:25. IHC-P: 1:25. IHC-P: 1:25. FC: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-CD11b antibody (ABIN654625)

Lavine, Kovacs, Weinheimer, Mann: "Repetitive myocardial ischemia promotes coronary growth in the adult mammalian heart." in: Journal of the American Heart Association, Vol. 2, Issue 5, pp. e000343, (2013) (PubMed).

Target Details for CD11b

Target: CD11b (ITGAM) (Integrin alpha M (ITGAM))

Alternative Name: CD11b

Background: CD11b is the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles.

Molecular Weight: 127179

Gene ID: 3684

NCBI Accession: NP_000623, NP_001139280

UniProt: P11215

Pathways: Apoptosis, Activation of Innate immune Response, Toll-Like Receptors Cascades, Activated T Cell Proliferation