PSMB11 antibody (C-Term)

Catalog No. ABIN2844876

Product Details anti-PSMB11 Antibody

Target: PSMB11 (Proteasome (Prosome, Macropain) Subunit, beta Type, 11 (PSMB11))

Binding Specificity: AA 250-278, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PSMB11 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This PSMB11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 250-278 amino acids from the C-terminal region of human PSMB11.

Clone: RB28790

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

Target Details for PSMB11

Target: PSMB11 (Proteasome (Prosome, Macropain) Subunit, beta Type, 11 (PSMB11))

Alternative Name: PSMB11 (PSMB11 Products)

Synonyms: BETA5T antibody, 5830406J20Rik antibody, beta5t antibody, proteasome subunit beta 11 antibody, proteasome (prosome, macropain) subunit, beta type, 11 antibody, PSMB11 antibody, Psmb11 antibody

Background: Proteasomes generate peptides that are presented by major histocompatibility complex (MHC) I molecules to other cells of the immune system. Proteolysis is conducted by 20S proteasomes, complexes of 28 subunits arranged as a cylinder in 4 heteroheptameric rings: alpha-1 to -7, beta-1 to -7, beta-1 to -7, and alpha-1 to -7. The catalytic subunits are beta-1 (PSMB6, MIM 600307), beta-2 (PSMB7, MIM 604030), and beta-5 (PSMB5, MIM 600306). Three additional subunits, beta-1i (PSMB9, MIM 177045), beta-2i (PSMB10, MIM 176847), and beta-5i (PSMB8, MIM 177046), are induced by gamma-interferon (IFNG, MIM 147570) and are preferentially incorporated into proteasomes to make immunoproteasomes. PSMB11, or beta-5t, is a catalytic subunit expressed exclusively in cortical thymic epithelial cells (Murata et al., 2007 [PubMed 17540904]).

Molecular Weight: 32530

Gene ID: 122706

NCBI Accession: NP_001093250

UniProt: A5LHX3