DDR1 antibody (PE)

Catalog No. ABIN6559828

The Mouse Monoclonal anti-DDR1 antibody is suitable to detect DDR1 in samples from Human. It has been validated for FACS.

Quick Overview for DDR1 antibody (PE) (ABIN6559828)

Target: DDR1 (Discoidin Domain Receptor tyrosine Kinase 1 (DDR1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This DDR1 antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Clone: 51D6

Product Details anti-DDR1 Antibody (PE)

Purpose: Anti-Hu CD167a PE

Cross-Reactivity (Details): Human

Characteristics: The mouse monoclonal antibody 51D6 recognizes an extracellular epitope of CD167a, an approximately 97-101 kDa receptor tyrosine kinase expressed mainly on epithelial cells, but also on B cells and dendritic cells.

Purification: Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

Immunogen: CD167a-transfected NIH-3T3 cells

Isotype: IgM

Application Details

Application Notes: Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 10⁶ cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Stabilizing Tris buffered saline (TBS), pH 8.0, 15 mM sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Do not freeze,Protect from prolonged exposure to light

Storage: 4 °C

Storage Comment: Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Target Details for DDR1

Target: DDR1 (Discoidin Domain Receptor tyrosine Kinase 1 (DDR1))

Alternative Name: CD167a

Background: Discoidin domain receptor tyrosine kinase 1,CD167a, also known as e.g. discoidin domain receptor tyrosine kinase 1 (DDR1), tyrosine kinase receptor E (TRKE), cell adhesion kinase (CAK), or neuroepithelial tyrosine kinase 4 (NEP, NTRK4), is a transmembrane receptor tyrosine kinase expressed predominantly in epithelial cells. It has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms of this protein have been described. After binding to fibrilar collagens I, II, III, V, or basement membrane collagens IV and VIII, CD167a becomes activated and autophosphorylated and transduces collagen-induced signaling.,EDDR1, MCK10, NTRK4, PTK3A, RTK6, CAK, TRKE, DDR1

Gene ID: 780

UniProt: Q08345

Pathways: RTK Signaling, Smooth Muscle Cell Migration