Synonyms: DFNB82,G protein signalling modulator 2 (AGS3 like C. elegans),G protein signalling modulator 2,G-protein-signaling modulator 2,Gpsm2,GPSM2,HGNC:29501,LGN,LGN protein,Mosaic protein LGN,Pins
Background: The protein encoded by this gene belongs to a family of proteins that modulate activation of G proteins, which transduce extracellular signals received by cell surface receptors into integrated cellular responses. The N-terminal half of this protein contains 10 copies of leu-gly-asn (LGN) repeat, and the C-terminal half contains 4 GoLoco motifs, which are involved in guanine nucleotide exchange. This protein may play a role in neuroblast division and in the development of normal hearing. Mutations in this gene are associated with autosomal recessive nonsyndromic deafness (DFNB82). Alternative splicing results in multiple transcript variants.