DYNC2LI1 antibody

Catalog No. ABIN6569748

Product Details anti-DYNC2LI1 Antibody

Target: DYNC2LI1 (Dynein, Cytoplasmic 2, Light Intermediate Chain 1 (DYNC2LI1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DYNC2LI1 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Affinity purification

Immunogen: Recombinant protein of human DYNC2LI1

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for DYNC2LI1

Target: DYNC2LI1 (Dynein, Cytoplasmic 2, Light Intermediate Chain 1 (DYNC2LI1))

Alternative Name: DYNC2LI1 (DYNC2LI1 Products)

Synonyms: DYNC2LI1 antibody, 4933404O11Rik antibody, CGI-60 antibody, D2lic antibody, LIC3 antibody, mD2LIC antibody, D2LIC antibody, dynein cytoplasmic 2 light intermediate chain 1 antibody, DYNC2LI1 antibody, Dync2li1 antibody

Background:

Synonyms: CGI-60,Cytoplasmic dynein 2 light intermediate chain 1,D2LIC,DC2L1,DYNC2LI1,Dynein 2 light intermediate chain,Dynein, cytoplasmic 2, light intermediate chain 1,LIC3

Background: This gene encodes a protein that is a component of the dynein-2 microtubule motor protein complex that plays a role in the retrograde transport of cargo in primary cilia via the intraflagellar transport system. This gene is ubiquitously expressed and its protein, which localizes to the axoneme and Golgi apparatus, interacts directly with the cytoplasmic dynein 2 heavy chain 1 protein to form part of the multi-protein dynein-2 complex. Mutations in this gene produce defects in the dynein-2 complex which result in several types of ciliopathy including short-rib thoracic dysplasia 15 with polydactyly (SRTD15). Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Molecular Weight:

Observed_MW: 38kDa

Calculated_MW: 15kDa/22kDa/37kDa/39kDa

Gene ID: 51626

UniProt: Q8TCX1

Pathways: Hedgehog Signaling