PHLPP1 antibody

Catalog No. ABIN6571995

This Rabbit Polyclonal antibody specifically detects PHLPP1 in IF. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for PHLPP1 antibody (ABIN6571995)

Target: PHLPP1 (PH Domain and Leucine Rich Repeat Protein Phosphatase 1 (PHLPP1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PHLPP1 antibody is un-conjugated

Application: Immunofluorescence (IF)

Product Details anti-PHLPP1 Antibody

Purification: Affinity purification

Immunogen: Recombinant fusion protein of human PHLPP1 (NP_919431.2).

Isotype: IgG

Application Details

Application Notes: IF 1:50-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for PHLPP1

Target: PHLPP1 (PH Domain and Leucine Rich Repeat Protein Phosphatase 1 (PHLPP1))

Alternative Name: PHLPP1

Background: This gene encodes a member of the serine/threonine phosphatase family. The encoded protein promotes apoptosis by dephosphorylating and inactivating the serine/threonine kinase Akt, and functions as a tumor suppressor in multiple types of cancer. Increased expression of this gene may also play a role in obesity and type 2 diabetes by interfering with Akt-mediated insulin signaling.

Molecular Weight:

Observed_MW: 185kDa

Calculated_MW: 133kDa/184kDa

Gene ID: 23239

UniProt: O60346

Pathways: PI3K-Akt Signaling, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway