PHLPP1 antibody (N-Term)

Catalog No. ABIN392310

Product Details anti-PHLPP1 Antibody

Target: PHLPP1 (PH Domain and Leucine Rich Repeat Protein Phosphatase 1 (PHLPP1))

Binding Specificity: AA 531-560, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PHLPP1 antibody is un-conjugated

Application: Western Blotting (WB)

Predicted Reactivity: M, Rat

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This PHLPP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 531-560 amino acids from the N-terminal region of human PHLPP1.

Clone: RB14892

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

Target Details for PHLPP1

Target: PHLPP1 (PH Domain and Leucine Rich Repeat Protein Phosphatase 1 (PHLPP1))

Alternative Name: PHLPP1 (PHLPP1 Products)

Synonyms: PHLPP antibody, PLEKHE1 antibody, SCOP antibody, AI836256 antibody, Phlpp antibody, Plekhe1 antibody, mKIAA0606 antibody, Scop antibody, PH domain and leucine rich repeat protein phosphatase 1 antibody, PHLPP1 antibody, phlpp1 antibody, Phlpp1 antibody

Background: PHLPP1 is a protein phosphatase that specifically mediates dephosphorylation of 'Ser-473' of AKT1, a protein that regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes.

Molecular Weight: 184672

Gene ID: 23239

NCBI Accession: NP_919431

UniProt: O60346

Pathways: PI3K-Akt Signaling, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway