NLRP12 antibody (N-Term)

Catalog No. ABIN657935

The Rabbit Polyclonal anti-NLRP12 antibody has been validated for WB and IHC (p). It is suitable to detect NLRP12 in samples from Human. There is 1 publication available.

Quick Overview for NLRP12 antibody (N-Term) (ABIN657935)

Target: NLRP12 (NLR Family, Pyrin Domain Containing 12 (NLRP12))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NLRP12 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB33963

Product Details anti-NLRP12 Antibody

Binding Specificity: AA 183-212, N-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This NLRP12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 183-212 amino acids from the N-terminal region of human NLRP12.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: NLRP12 Antibody (N-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.

Expiry Date: 6 months

References for anti-NLRP12 antibody (ABIN657935)

Cai, Batra, Del Piero, Jeyaseelan: "NLRP12 modulates host defense through IL-17A-CXCL1 axis." in: Mucosal immunology, (2015) (PubMed).

Target Details for NLRP12

Target: NLRP12 (NLR Family, Pyrin Domain Containing 12 (NLRP12))

Alternative Name: NLRP12

Background: This gene encodes a member of the CATERPILLER family of cytoplasmic proteins. The encoded protein, which contains an N-terminal pyrin domain, a NACHT domain, a NACHT-associated domain, and a C-terminus leucine-rich repeat region, functions as an attenuating factor of inflammation by suppressing inflammatory responses in activated monocytes. Alternatively spliced transcript variants encoding distinct isoforms have been described but the full-length nature of some of these has not been determined.

Molecular Weight: 120173

Gene ID: 91662

NCBI Accession: NP_001264055, NP_001264058, NP_653288

UniProt: P59046

Pathways: Positive Regulation of Endopeptidase Activity, Inflammasome