Neuregulin 3 antibody (AA 311-360)

Catalog No. ABIN6579621

This Rabbit Polyclonal antibody specifically detects Neuregulin 3 in WB, IHC, ELISA and IF. It exhibits reactivity toward Human and Mouse.

Quick Overview for Neuregulin 3 antibody (AA 311-360) (ABIN6579621)

Target: Neuregulin 3 (NRG3)

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Neuregulin 3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Product Details anti-Neuregulin 3 Antibody

Binding Specificity: AA 311-360

Purpose: Neuregulin-3 Antibody

Specificity: Neuregulin-3 Polyclonal Antibody detects endogenous levels of Neuregulin-3 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: The antiserum was produced against synthesized peptide derived from the Internal region of human NRG3. AA range:311-360

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000. IHC: 1:100-1:300. ELISA: 1:10000.. IF 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for Neuregulin 3

Target: Neuregulin 3 (NRG3)

Alternative Name: NRG3

Background:

Synonyms: NRG3, Pro-neuregulin-3, membrane-bound isoform, Pro-NRG3

Background: This gene is a member of the neuregulin gene family. This gene family encodes ligands for the transmembrane tyrosine kinase receptors ERBB3 and ERBB4 - members of the epidermal growth factor receptor family. Ligand binding activates intracellular signaling cascades and the induction of cellular responses including proliferation, migration, differentiation, and survival or apoptosis.This gene encodes neuregulin 3 (NRG3). NRG3 has been shown to activate the tyrosine phosphorylation of its cognate receptor, ERBB4, and is thought to influence neuroblast proliferation, migration and differentiation by signalling through ERBB4. NRG3 also promotes mammary differentiation during embryogenesis. Linkage studies have implicated this gene as a susceptibility locus for schizophrenia and schizoaffective disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcri

Gene Name: NRG3

Protein Name: Pro-neuregulin-3 membrane-bound isoform

Molecular Weight: '77 kDa

Gene ID: 10718

OMIM: 605533

UniProt: P56975

Pathways: RTK Signaling