Perforin 1 antibody (AA 451-500)

Catalog No. ABIN6579662

The Rabbit Polyclonal anti-Perforin 1 antibody (ABIN6579662) specifically detects Perforin 1 in WB, IHC and ELISA. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for Perforin 1 antibody (AA 451-500) (ABIN6579662)

Target: Perforin 1 (PRF1) (Perforin 1 (Pore Forming Protein) (PRF1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Perforin 1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-Perforin 1 Antibody

Binding Specificity: AA 451-500

Purpose: Perforin 1 Antibody

Specificity: Perforin 1 Polyclonal Antibody detects endogenous levels of Perforin 1

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: The antiserum was produced against synthesized peptide derived from the C-terminal region of human PRF1. AA range:451-500

Isotype: IgG

Application Details

Application Notes: WB 1:500-2000, IHC 1:50-200, ELISA 1:10000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for Perforin 1

Target: Perforin 1 (PRF1) (Perforin 1 (Pore Forming Protein) (PRF1))

Alternative Name: PRF1

Background:

Synonyms: Perforin-1 (P1) (Cytolysin) (Lymphocyte pore-forming protein) (PFP)

Background: The protein encoded by this gene has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008],

Gene Name: PRF1

Protein Name: Perforin 1

Molecular Weight: 61 kDa

Gene ID: 5551

OMIM: 170280

UniProt: P14222

Pathways: Apoptosis, Caspase Cascade in Apoptosis