Recombinant HLA DQ antibody (full length)

Catalog No. ABIN6654368

The Rabbit Monoclonal anti-HLA DQ antibody (Clone HLA-DQA1-2866R) (ABIN6654368) specifically detects HLA DQ in FACS and IF. The antibody is reactive with Human samples.

Quick Overview for Recombinant HLA DQ antibody (full length) (ABIN6654368)

Target: HLA DQ (HLA-DQ) (MHC Class II HLA-DQ (HLA-DQ))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This HLA DQ antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunofluorescence (IF)

Clone: HLA-DQA1-2866R

Product Details anti-HLA DQ Antibody

Binding Specificity: full length

Purpose: Recombinant HLA-DQ Antibody (MHC II)

Purification: Protein A affinity chromatography

Immunogen: Full length recombinant human protein was used as the immunogen for the recombinant HLA-DQ antibody.

Isotype: IgG, kappa

Application Details

Application Notes: Optimal dilution of the recombinant HLA-DQ antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store the recombinant HLA-DQ antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for HLA DQ

Target: HLA DQ (HLA-DQ) (MHC Class II HLA-DQ (HLA-DQ))

Alternative Name: HLA-DQ

Background: Recognizes a DQ antigen, which is a dimer of 60 kDa. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons, exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation.

UniProt: P01908