THRB antibody (N-Term)

Catalog No. ABIN6655581

Supplier Product No.: 209-301-a96

Product Details anti-THRB Antibody

Target: THRB (Thyroid Hormone Receptor, beta (THRB))

Binding Specificity: N-Term

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This THRB antibody is un-conjugated

Application: Western Blotting (WB)

Supplier Product No.: 209-301-a96

Supplier: Rockland

Purpose: Thyroid Hormone Receptor beta Antibody

Cross-Reactivity (Details): Thyroid Hormone Receptor beta antibody is purified by Protein G chromatography from cell culture supernatant.

Purification: Anti-Thyroid Hormone Receptor beta antibody is directed against human TRβ.

Immunogen: Anti-Thyroid Hormone Receptor beta monoclonal antibody was produced in mouse by repeated immunizations with synthetic peptide corresponding to amino acid residues from the N-terminal region of Thyroid Hormone Receptor beta.

Clone: 2386

Isotype: IgG1

Application Details

Application Notes: Optional[Neutralization_Dilution]: 1:1000

Comment:

Suggested Applications: IHC
Anti-Thyroid Hormone Receptor beta (Mouse) antibody is tested for use in Western Blotting. Expect a band of approximately 55 kDa corresponding to TR-β proteins in the appropriate cell lysate or extract. Researchers should determine optimal titers for applications that are not stated below.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer:

Buffer: 0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5

Stabilizer: 0.1 mg/mL Bovine Serum Albumin (BSA) - IgG and Protease free, 50 % (v/v) Glycerol

Storage: 4 °C,-20 °C

Storage Comment: Store vial at -20° C prior to opening.  This product is stable at 4° C as an undiluted liquid.  For extended storage, aliquot contents and freeze at -20° C or below.  Avoid cycles of freezing and thawing. Dilute only prior to immediate use.

Expiry Date: 12 months

References for anti-THRB antibody (ABIN6655581)

Aksoy, Pencik, Hartenbach, Moazzami, Schlederer, Balber, Varady, Philippe, Baltzer, Mazumder, Whitchurch, Roberts, Haitel, Herac, Susani, Mitterhauser, Marculescu, Stangl-Kremser, Hassler, Kramer, Shariat, Turner, Tichy, Oppelt, Pospisilova, Hartenbach, T: "Thyroid and androgen receptor signaling are antagonized by μ-Crystallin in prostate cancer." in: International journal of cancer, Vol. 148, Issue 3, pp. 731-747, (2021) (PubMed).

Schnoell, Kotowski, Jank, Stoiber, Gurnhofer, Schlederer, Heiduschka, Kenner, Kadletz-Wanke: "Prognostic Relevance of Thyroid-Hormone-Associated Proteins in Adenoid Cystic Carcinoma of the Head and Neck." in: Journal of personalized medicine, Vol. 11, Issue 12, (2021) (PubMed).

Target Details for THRB

Target: THRB (Thyroid Hormone Receptor, beta (THRB))

Alternative Name: Thyroid Hormone Receptor beta (THRB Products)

Background:

Synonyms: mouse anti-Thyroid Hormone Receptor beta Antibody, mouse anti-Thrb antibody, Nuclear receptor subfamily 1 group A member 2, c-erbA-2, c-erbA-beta

Background: Thyroid Hormone Receptor beta antibody detects Thyroid Hormone Receptor beta. Thyroid hormones are essential for development of the central nervous system and deficits in these hormones during development affects such cognitive functions as learning and memory. Thyroid hormones exert their physiological role mainly through binding to specific nuclear receptors including the predominant isoforms of thyroid hormone receptors TRα1, TRα2, TRβ1 and TRβ2. TRα1, TRβ1 and TRβ2 bind T3 with high affinity and also bind to thyroid hormone response elements (TREs) on chromatin to regulate the transcriptional processes in several target tissues, including adult rat brain. Thyroid Hormone Receptor beta antibody is ideal for investigators involved in Cell Signaling, Neuroscience, Signal Transduction research.

Gene Name: THRB

Gene ID: 7068

NCBI Accession: NP_000452

UniProt: P10828

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Sensory Perception of Sound