KCNMB2 antibody (C-Term, N-Term)

Catalog No. ABIN6657685

Product Details anti-KCNMB2 Antibody

Target: KCNMB2 (Potassium Large Conductance Calcium-Activated Channel, Subfamily M, beta Member 2 (KCNMB2))

Binding Specificity: C-Term, N-Term

Reactivity: Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This KCNMB2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

Cross-Reactivity: Human, Mouse (Murine), Rat (Rattus)

Purification: Anti-BK channel BETA2 Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with BK channel BETA2 from human, mouse, and rat based on 100% homology with the immunizing sequence. Detects endogenous and exogenous hsp22 in monomeric, dimeric and tetrameric forms in WB. Does not cross react with alpha crystallin. Cross-reactivity with BK channel BETA2 from other sources has not been determined. Ion Channels research.

Immunogen:

Immunogen: BK channel BETA2 Antibody was produced in mice by repeated immunizations with a fusion protein N-terminus and C-terminus regions of mouse BKBeta2.

Immunogen Type: Recombinant Protein

Clone: S53-32

Isotype: IgG1

Application Details

Application Notes:

Immunohistochemistry Dilution: User Optimized

Application Note: Anti-BK channel Beta3 Antibody is suitable for use in WB, IP, and IHC. Specific conditions for reactivity should be optimized by the end user.

Immunoprecipitation Dilution: User Optimized

Western Blot Dilution: 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer:

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Stabilizer: 50 % (v/v) Glycerol

Storage: RT,4 °C,-20 °C

Storage Comment: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Target Details for KCNMB2

Target: KCNMB2 (Potassium Large Conductance Calcium-Activated Channel, Subfamily M, beta Member 2 (KCNMB2))

Alternative Name: BK channel BETA2 (KCNMB2 Products)

Synonyms: KCNMB3 antibody, zgc:101842 antibody, KCNMB2 antibody, 2700049B16Rik antibody, 3110031N04Rik antibody, Kcmb2 antibody, potassium calcium-activated channel subfamily M regulatory beta subunit 2 antibody, potassium large conductance calcium-activated channel, subfamily M, beta member 2 antibody, KCNMB2 antibody, kcnmb2 antibody, Kcnmb2 antibody

Background:

Synonyms: KCNMB2, Calcium-activated potassium channel subunit beta-2, BK channel subunit beta-2, BKbeta2, Calcium-activated potassium channel, subfamily M subunit beta-2, Charybdotoxin receptor subunit beta-2, K(VCA)beta-2, Maxi K channel subunit beta-2, Slo-beta-2

Background: BK channels contribute to electrical impulses, proper signal transmission of information and regulation of neurotransmitter release. A gain of function mutation in the pore-forming alpha subunit of the BK channel was linked to human neurological diseases. Findings suggest that the distribution of the beta subunits in the brain can modulate the BK channels to contribute to the pathophysiology of epilepsy and dyskinesia. This has major implications on other physiological processes in tissues other than the brain.

Gene Name: Kcnmb2

Gene ID: 72413

NCBI Accession: NP_082507

UniProt: Q9CZM9