Kv3.4 antibody (Internal Region)

Catalog No. ABIN6658110

Product Details anti-Kv3.4 Antibody

Target: Kv3.4 (KCNC4) (Potassium Voltage-Gated Channel, Shaw-Related Subfamily, Member 4 (KCNC4))

Binding Specificity: Internal Region

Reactivity: Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This Kv3.4 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Fluorescence Microscopy (FM)

Cross-Reactivity: Human, Mouse (Murine), Rat (Rattus)

Purification: Anti-KV3.4 Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with KV3.4 from human, mouse, and rat based on 100% homology with the immunizing sequence. Cross-reactivity with KV3.4 from other sources has not been determined. Ion Channels research.

Immunogen:

Immunogen: KV3.4 Antibody was produced in mice by repeated immunizations raised against a synthetic peptide corresponding to an internal region of rat Kv3.4.

Immunogen Type: Peptide

Clone: S72-16

Isotype: IgG1

Application Details

Application Notes:

Immunohistochemistry Dilution: 0.1-1.0 μg/mL

Application Note: Anti-KV3.4 Antibody is suitable for use in WB, IHC and IP. Expect a band approximately ~70 kDa on specific lysates (100 kDa in brain due to glycosylation). Specific conditions for reactivity should be optimized by the end user.

Immunoprecipitation Dilution: User Optimized

Western Blot Dilution: 1-10 μg/mL

IF Microscopy Dilution: 1.0-10 μg/mL

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer:

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Stabilizer: 50 % (v/v) Glycerol

Storage: RT,4 °C,-20 °C

Storage Comment: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Target Details for Kv3.4

Target: Kv3.4 (KCNC4) (Potassium Voltage-Gated Channel, Shaw-Related Subfamily, Member 4 (KCNC4))

Alternative Name: KV3.4 (KCNC4 Products)

Synonyms: C1orf30 antibody, HKSHIIIC antibody, KSHIIIC antibody, KV3.4 antibody, AI850292 antibody, Kcr2-4 antibody, Kv3.4 antibody, potassium voltage-gated channel subfamily C member 4 antibody, potassium channel, voltage gated Shaw related subfamily C, member 4 antibody, potassium voltage gated channel, Shaw-related subfamily, member 4 antibody, KCNC4 antibody, kcnc4 antibody, Kcnc4 antibody

Background:

Synonyms: Raw3, Voltage-gated potassium channel subunit Kv3.4, Potassium voltage-gated channel subfamily C member 4

Background: Kv3.4, a member of the Shaw subfamily, may play important roles in maintaining normal function of the corneal epithelium. Kv3.4 is also over-expressed in the early stages of Alzheimer's disease, and therefore represents a novel therapeutic target for this disease.

Gene Name: Kcnc4

Gene ID: 684516

NCBI Accession: NP_001116248

UniProt: Q63734