KCND2 antibody (Extracellular Domain)

Catalog No. ABIN6658239

Supplier Product No.: 200-301-g03

This Mouse Monoclonal antibody specifically detects KCND2 in WB, IHC, IP and FM. It exhibits reactivity toward Rat. It has been mentioned in 2+ publications

Quick Overview for KCND2 antibody (Extracellular Domain) (ABIN6658239)

Target: KCND2 (Potassium Voltage-Gated Channel, Shal-Related Subfamily, Member 2 (KCND2))

Reactivity: Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This KCND2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Fluorescence Microscopy (FM)

Clone: S57-1

Product Details anti-KCND2 Antibody

Binding Specificity: Extracellular Domain

Supplier Product No.: 200-301-g03

Supplier: Rockland

Purpose: Kv4.2 K+ channel Antibody

Purification: Anti-Kv4.2 K+ channel Antibody was purified by Protein G chromatography.

Sterility: Sterile filtered

Immunogen: Kv4.2 K+ channel Antibody was produced in mice by repeated immunizations raised against a synthetic peptide corresponding to an extracellular S1-S2 loop region of rat Kv4.2.

Isotype: IgG1

Application Details

Application Notes:

Immunoprecipitation_Dilution: User Optimized

Immunohistochemistry_Dilution: 0.1-1.0 μg/mL

IF_Microscopy_Dilution: 1.0-10 μg/mL

Western_Blot_Dilution: 1 μg/mL

Comment:

Anti-Kv4.2 K+ channel Antibody is tested for use in WB, IP, and IHC. Expect a band approximately ~75-80kDa on specific lysates. Specific conditions for reactivity should be optimized by the end user.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer:

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Stabilizer: 50 % (v/v) Glycerol

Storage: 4 °C,-20 °C

Storage Comment: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Expiry Date: 12 months

References for anti-KCND2 antibody (ABIN6658239)

Duan, Krishnaswamy, Laboulaye, Liu, Peng, Yamagata, Toma, Sanes: "Cadherin Combinations Recruit Dendrites of Distinct Retinal Neurons to a Shared Interneuronal Scaffold." in: Neuron, Vol. 99, Issue 6, pp. 1145-1154.e6, (2019) (PubMed).

Peng, Tran, Krishnaswamy, Kostadinov, Martersteck, Sanes: "Satb1 Regulates Contactin 5 to Pattern Dendrites of a Mammalian Retinal Ganglion Cell." in: Neuron, Vol. 95, Issue 4, pp. 869-883.e6, (2017) (PubMed).

Target Details for KCND2

Target: KCND2 (Potassium Voltage-Gated Channel, Shal-Related Subfamily, Member 2 (KCND2))

Alternative Name: Kcnd2

Background:

Synonyms: RK5, Kv4.2, Shal1, Kcnd2, Potassium voltage-gated channel subfamily D member 2,Voltage-gated potassium channel subunit Kv4.2

Background: The Kv4.2 potassium channel is a voltage-gated channel protein which belongs to the delayed rectifier class and to the ShaI potassium channel subfamily. All of the KV channels can product delayed-rectifier and transient ""A-type"" currents, all members of the KV4 subfamily mediate IA. Kv4 channels in the central nervous system localize to the soma and dendrites, and therefore are responsible for the somato-dendritic A-type K+ current (ISA).

Gene Name: Kcnd2

Gene ID: 65180

NCBI Accession: NP_113918

UniProt: Q63881