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KCND2 antibody (AA 501-630)

KCND2 Reactivity: Human IHC, ELISA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7163978
  • Target See all KCND2 Antibodies
    KCND2 (Potassium Voltage-Gated Channel, Shal-Related Subfamily, Member 2 (KCND2))
    Binding Specificity
    • 15
    • 10
    • 9
    • 8
    • 7
    • 5
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 501-630
    Reactivity
    • 55
    • 36
    • 34
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 55
    • 3
    • 1
    Rabbit
    Clonality
    • 56
    • 3
    Polyclonal
    Conjugate
    • 27
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This KCND2 antibody is un-conjugated
    Application
    • 45
    • 26
    • 23
    • 13
    • 9
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Immunohistochemistry (IHC), ELISA
    Cross-Reactivity
    Human
    Purification
    Antigen Affinity Purified
    Immunogen
    Recombinant Human Potassium voltage-gated channel subfamily D member 2 protein (501-630AA)
    Isotype
    IgG
    Top Product
    Discover our top product KCND2 Primary Antibody
  • Application Notes
    Recommended dilution: IHC:1:20-1:200,
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    KCND2 (Potassium Voltage-Gated Channel, Shal-Related Subfamily, Member 2 (KCND2))
    Alternative Name
    KCND2 (KCND2 Products)
    Synonyms
    KCND2 antibody, si:dkey-24j9.3 antibody, si:dkeyp-97c5.3 antibody, DKFZp459P1550 antibody, AI839615 antibody, AW555701 antibody, Kv4.2 antibody, R75121 antibody, mKIAA1044 antibody, KV4.2 antibody, RK5 antibody, Shal1 antibody, potassium voltage-gated channel subfamily D member 2 antibody, potassium voltage-gated channel, Shal-related subfamily, member 2 antibody, potassium voltage-gated channel, Shal-related family, member 2 antibody, KCND2 antibody, kcnd2 antibody, Kcnd2 antibody, LOC101669961 antibody
    Background

    Background: Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain. Mediates the major part of the dendritic A-type current I(SA) in brain neurons (By similarity). This current is activated at membrane potentials that are below the threshold for action potentials. It regulates neuronal excitability, prolongs the latency before the first spike in a series of action potentials, regulates the frequency of repetitive action potential firing, shortens the duration of action potentials and regulates the back-propagation of action potentials from the neuronal cell body to the dendrites. Contributes to the regulation of the circadian rhytm of action potential firing in suprachiasmatic nucleus neurons, which regulates the circadian rhythm of locomotor activity (By similarity). Functions downstream of the metabotropic glutamate receptor GRM5 and plays a role in neuronal excitability and in nociception mediated by activation of GRM5 (By similarity). Mediates the transient outward current I(to) in rodent heart left ventricle apex cells, but not in human heart, where this current is mediated by another family member. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient (PubMed:10551270, PubMed:15454437, PubMed:14695263, PubMed:14623880, PubMed:14980201, PubMed:16934482, PubMed:24811166, PubMed:24501278). The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:11507158). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCND2 and KCND3, channel properties depend on the type of pore-forming alpha subunits that are part of the channel. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes. Interaction with specific isoforms of the regulatory subunits KCNIP1, KCNIP2, KCNIP3 or KCNIP4 strongly increases expression at the cell surface and thereby increases channel activity, it modulates the kinetics of channel activation and inactivation, shifts the threshold for channel activation to more negative voltage values, shifts the threshold for inactivation to less negative voltages and accelerates recovery after inactivation (PubMed:15454437, PubMed:14623880, PubMed:14980201, PubMed:19171772, PubMed:24501278, PubMed:24811166). Likewise, interaction with DPP6 or DPP10 promotes expression at the cell membrane and regulates both channel characteristics and activity (By similarity).

    Aliases: KCD2 antibody, KCND 2 antibody, KCND2 antibody, KCND2_HUMAN antibody, KIAA1044 antibody, MGC119702 antibody, MGC119703 antibody, Potassium voltage gated channel Shal related subfamily member 2 antibody, Potassium voltage-gated channel subfamily D member 2 antibody, RK 5 antibody, RK5 antibody, Voltage gated potassium channel Kv4.2 antibody, Voltage gated potassium channel subunit Kv4.2 antibody, Voltage sensitive potassium channel antibody, Voltage-gated potassium channel subunit Kv4.2 antibody

    UniProt
    Q9NZV8
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