mGluR2/3 antibody (C-Term)

Catalog No. ABIN6658279

Supplier Product No.: 612-401-d63

The Rabbit Polyclonal anti-mGluR2/3 antibody is suitable to detect mGluR2/3 in samples from Rat. It has been validated for WB.

Quick Overview for mGluR2/3 antibody (C-Term) (ABIN6658279)

Target: mGluR2/3 (GRIA2/3) (Glutamate Receptor, Ionotropic, AMPA 2/3 (GRIA2/3))

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This mGluR2/3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-mGluR2/3 Antibody

Binding Specificity: C-Term

Supplier Product No.: 612-401-d63

Supplier: Rockland

Purpose: GluR2/3 Antibody

Cross-Reactivity (Details): Anti-GluR2/3 Antibody is directed against rat GluR2/3 protein.

Purification: The antibody was affinity purified from monospecific antiserum by immunoaffinity purification.

Immunogen: Anti-GluR2/3 Antibody was produced by repeated immunizations with synthetic peptide corresponding to amino acid residues from the C-terminal region.

Isotype: IgG

Application Details

Application Notes: Optional[Neutralization_Dilution]: 1:1000

Comment:

Anti-GluR2/3 (Rabbit) antibody is tested for use in Western Blotting. Specific conditions for reactivity should be optimized by the end user. Expect a band of approximately 100 kDa in size corresponding to GluR2/3 protein in the appropriate cell lysate or extract.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer:

Buffer: 0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5

Stabilizer: 0.1 mg/mL Bovine Serum Albumin (BSA) - IgG and Protease free, 50 % (v/v) Glycerol

Storage: 4 °C,-20 °C

Storage Comment: Store vial at -20° C prior to opening.  This product is stable at 4° C as an undiluted liquid.  For extended storage, aliquot contents and freeze at -20° C or below.  Avoid cycles of freezing and thawing. Dilute only prior to immediate use.

Expiry Date: 12 months

Target Details for mGluR2/3

Target: mGluR2/3 (GRIA2/3) (Glutamate Receptor, Ionotropic, AMPA 2/3 (GRIA2/3))

Alternative Name: GluR2/3

Background:

Synonyms: Glutamate receptor 2, AMPA-selective glutamate receptor 2, GluR-B, GluR-K2, Glutamate receptor ionotropic, AMPA 2, GluA2

Background: GluR2/3 Antibody detects GluR2/3 protein. The ion channels activated by glutamate are typically divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR) while those activated by α-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known as AMPA receptors (AMPAR). The AMPAR are comprised of four distinct glutamate receptor subunits designated (GluR1-4) and they play key roles in virtually all excitatory neurotransmission in the brain. The GluR2 subunit is widely expressed throughout the nervous system where it is thought to play key roles in synaptic plasticity and learning and memory. Therefore, GluR2/3 is ideal for investigators involved in synaptic plasticity study and more in general in Neuroscience.

Gene Name: GRIA2/3

Gene ID: 29627

UniProt: P19491