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ITGB1 antibody (Integrin beta 1) (Biotin) Primary Antibody

ITGB1 Reactivity: Human, Dog, Pig FACS, IP, WB Host: Mouse Monoclonal MEM-101A Biotin
Pubmed (2)
Catalog No. ABIN94055
$455.40
Plus shipping costs $45.00
0.1 mg
local_shipping Shipping to: United States
Delivery in 5 to 7 Business Days
  • Target
    ITGB1
    Reactivity
    Human, Dog, Pig
    • 249
    • 99
    • 83
    • 15
    • 10
    • 10
    • 10
    • 7
    • 7
    • 6
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Host
    Mouse
    • 156
    • 105
    • 19
    • 7
    • 2
    • 1
    Clonality
    Monoclonal
    • 145
    • 140
    • 1
    Conjugate
    This ITGB1 antibody is conjugated to Biotin
    • 129
    • 28
    • 26
    • 19
    • 10
    • 10
    • 9
    • 9
    • 6
    • 6
    • 6
    • 6
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Application
    Flow Cytometry (FACS), Immunoprecipitation (IP), Western Blotting (WB)
    • 138
    • 134
    • 80
    • 65
    • 48
    • 33
    • 30
    • 26
    • 26
    • 23
    • 16
    • 7
    • 7
    • 6
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    Specificity
    The antibody MEM-101A reacts with CD29 (integrin beta1 chain), a 130 kDa single chain type I glycoprotein expressed as a heterodimer (non-covalently associated with the integrin alpha subunits 1-6). CD29 is broadly expressed on majority of hematopoietic and non-hematopoietic cells (leukocytes, platelets, fibroblasts, endothelial cells, epithelial cells and mast cells).
    HLDA VI, WS Code AS A048
    No Cross-Reactivity
    Mouse (Murine)
    Cross-Reactivity (Details)
    Human, Porcine, Canine (Dog)
    Immunogen
    Raji Burkitt's lymphoma cell line
    Clone
    MEM-101A
    Isotype
    IgG1
  • Application Notes
    Biotinylated antibody is designed for indirect immunofluorescence analysis by Flow Cytometry.Suggested working dilution is 1:1000. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.
    Comment

    The purified antibody is conjugated with Biotin-LC-NHS under optimum conditions. The reagent is free of unconjugated biotin.

    Restrictions
    For Research Use only
  • Concentration
    1 mg/mL
    Buffer
    Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Do not freeze.
    Avoid prolonged exposure to light.
    Storage
    4 °C
    Storage Comment
    Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label.
  • Plánka, Necas, Srnec, Rauser, Starý, Jancár, Amler, Filová, Hlucilová, Kren, Gál: "Use of allogenic stem cells for the prevention of bone bridge formation in miniature pigs." in: Physiological research / Academia Scientiarum Bohemoslovaca, Vol. 58, Issue 6, pp. 885-93, 2010 (PubMed).

    Símová, Klíma, Cermak, Sourková, Andera: "Arf and Rho GAP adapter protein ARAP1 participates in the mobilization of TRAIL-R1/DR4 to the plasma membrane." in: Apoptosis : an international journal on programmed cell death, Vol. 13, Issue 3, pp. 423-36, 2008 (PubMed).

  • Target
    ITGB1
    Alternative Name
    CD29 (ITGB1 Antibody Abstract)
    Synonyms
    cd29, fnrb, gpiia, itgb1, mdf2, msk12, vla-beta, vlab, CD29, 4633401G24Rik, AA409975, AA960159, ENSMUSG00000051907, Fnrb, Gm9863, gpIIa, FNRB, GPIIA, MDF2, MSK12, VLA-BETA, VLAB, integrin subunit beta 1 S homeolog, integrin subunit beta 1, integrin beta 1 (fibronectin receptor beta), itgb1.S, ITGB1, Itgb1
    Background
    CD29 (beta1 integrin subunit, GPIIa) forms non-covalently linked heterodimers with at least 6 different alpha chains (alpha1-alpha6, CD49a-f) determining the binding properties of beta1 (VLA) integrins. These integrins mediate cell adhesion to collagen, fibronectin, laminin and other extracellular matrix (ECM) components. This interaction hinders cell death, whereas disruption of anchorage to ECM leads to apoptosis. Decreased expression of most beta1 integrins correlates with acquiring multidrug resistance of tumour cells during selection in presence of antitumour drug. In platelets, translocation of intracellular pool of beta1 integrins to the plasma membrane following thrombin stimulation. These integrins are also up-regulated in leukocytes during emigration and extravascular migration and appear to be critically involved in regulating the immune cell trafficking from blood to tissue, as well as in regulating tissue damage and disease symptoms related to inflammatory bowel disease. Through a beta1 integrin-dependent mechanism, fibronectin and type I collagen enhance cytokine secretion of human airway smooth muscle in response to IL-1beta.
    Pathways
    Cell-Cell Junction Organization, Regulation of G-Protein Coupled Receptor Protein Signaling, CXCR4-mediated Signaling Events, Signaling of Hepatocyte Growth Factor Receptor, Integrin Complex, SARS-CoV-2 Protein Interactome
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