Integrin beta 2 antibody (AA 701-770)

Catalog No. ABIN669411

This anti-Integrin beta 2 antibody is a Rabbit Polyclonal antibody detecting Integrin beta 2 in ELISA, IHC (fro), ICC, IHC (p), IF (cc) and IF (p). Suitable for Human and Rat. This Primary Antibody has been cited in 2+ publications.

Quick Overview for Integrin beta 2 antibody (AA 701-770) (ABIN669411)

Target: Integrin beta 2 (ITGB2)

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Integrin beta 2 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-Integrin beta 2 Antibody

Binding Specificity: AA 701-770

Cross-Reactivity: Human, Rat

Predicted Reactivity: Mouse,Cow,Sheep,Pig,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Integrin beta 2

Isotype: IgG

Application Details

Application Notes: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-Integrin beta 2 antibody (ABIN669411)

Eppler, Quast, Kolanus: "Dynamin2 controls Rap1 activation and integrin clustering in human T lymphocyte adhesion." in: PLoS ONE, Vol. 12, Issue 3, pp. e0172443, (2017) (PubMed).

Chenna Narendra, Chalise, Magnusson, Uppugunduri: "Local but Not Systemic Administration of Uridine Prevents Development of Antigen-Induced Arthritis." in: PLoS ONE, Vol. 10, Issue 10, pp. e0141863, (2015) (PubMed).

Target Details for Integrin beta 2

Target: Integrin beta 2 (ITGB2)

Alternative Name: CD18

Background:

Synonyms: LAD, CD18, MF17, MFI7, LCAMB, LFA-1, MAC-1, Integrin beta-2, Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta, Complement receptor C3 subunit beta, ITGB2

Background: Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation.

Gene ID: 3689

UniProt: P05107

Pathways: NF-kappaB Signaling, Activation of Innate immune Response, Toll-Like Receptors Cascades, Activated T Cell Proliferation