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DOK7 antibody (Docking Protein 7) Primary Antibody

DOK7 Reactivity: Human, Mouse, Rat ICC, IF, IHC (p), WB Host: Rabbit Polyclonal
Catalog No. ABIN6719428
$280.00
Plus shipping costs $45.00
100 μg
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  • Target
    Reactivity
    Human, Mouse, Rat
    Host
    Rabbit
    Clonality
    Polyclonal
    Conjugate
    This DOK7 antibody is un-conjugated
    Application
    Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
    Purpose
    Rabbit IgG polyclonal antibody for DOK7 detection. Tested with WB, IHC-P, ICC/IF in Human,Mouse,Rat.
    Sequence
    STVEERVAQE ALETLQLEKR LSLLSHAGR
    Cross-Reactivity (Details)
    No cross reactivity with other proteins.
    Characteristics
    Rabbit IgG polyclonal antibody for DOK7 detection. Tested with WB, IHC-P, ICC/IF in Human,Mouse,Rat.
    Purification
    Immunogen affinity purified.
    Immunogen
    A synthetic peptide corresponding to a sequence of human DOK7(STVEERVAQEALETLQLEKRLSLLSHAGR).
    Isotype
    IgG
  • Target
    Alternative Name
    DOK7 (DOK7 Antibody Abstract)
    Background

    Synonyms: Protein Dok-7, Downstream of tyrosine kinase 7, DOK7, C4orf25,

    Background: Dok-7 is a non-catalytic cytoplasmic adaptor protein that is expressed specifically in muscle and is essential for the formation of neuromuscular synapses. Further, Dok-7 contains pleckstrin homology (PH) and phosphotyrosine-binding (PTB) domains that are critical for Dok-7 function. It is mapped to 4p16.3. The protein encoded by this gene is essential for neuromuscular synaptogenesis. The protein functions in aneural activation of muscle-specific receptor kinase, which is required for postsynaptic differentiation, and in the subsequent clustering of the acetylcholine receptor in myotubes. This protein can also induce autophosphorylation of muscle-specific receptor kinase. Mutations in this gene are a cause of familial limb-girdle myasthenia autosomal recessive, which is also known as congenital myasthenic syndrome type 1B. Alternative splicing results in multiple transcript variants.

    Gene ID
    285489
    Pathways
    Skeletal Muscle Fiber Development
  • Application Notes

    Application details: Western blot|0.1-0.5&mu,g/mL Immunohistochemistry(Paraffin-embedded Section)|0.5-1&mu,g/mL Immunocytochemistry/Immunofluorescence|2&mu,g/mL

    Comment

    Tested Species: In-house tested species with positive results. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Buffer
    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
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