Apoptosis Inhibitor 5 antibody (AA 351-460)

Catalog No. ABIN673959

The Rabbit Polyclonal anti-Apoptosis Inhibitor 5 antibody (ABIN673959) specifically detects Apoptosis Inhibitor 5 in WB, IF, IHC (p) and IHC (fro). The antibody is reactive with Human samples.

Quick Overview for Apoptosis Inhibitor 5 antibody (AA 351-460) (ABIN673959)

Target: Apoptosis Inhibitor 5 (API5)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Apoptosis Inhibitor 5 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-Apoptosis Inhibitor 5 Antibody

Binding Specificity: AA 351-460

Purpose: API5 Polyclonal Antibody

Cross-Reactivity: Mouse

Predicted Reactivity: Human,Rat,Dog,Cow,Pig,Horse,Guinea Pig

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human API5

Isotype: IgG

Application Details

Application Notes: WB(1:500-2000), IHC-P(1:100-500), IHC-F(1:100-500), IF(1:100-500)

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for Apoptosis Inhibitor 5

Target: Apoptosis Inhibitor 5 (API5)

Alternative Name: API5

Background:

Synonyms: AAC11, AAC-11, Apoptosis inhibitor 5, API-5, Antiapoptosis clone 11 protein, Cell migration-inducing gene 8 protein, Fibroblast growth factor 2-interacting factor, FIF, Protein XAGL, API5, MIG8

Background: Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs.

Gene ID: 8539

UniProt: Q9BZZ5

Pathways: Growth Factor Binding