OXSR1 antibody (AA 201-300) (Cy5.5)

Catalog No. ABIN681813

Product Details anti-OXSR1 Antibody (Cy5.5)

Target: OXSR1 (Oxidative-Stress Responsive 1 (OXSR1))

Binding Specificity: AA 201-300

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This OXSR1 antibody is conjugated to Cy5.5

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Pig,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human OXSR1.

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for OXSR1

Target: OXSR1 (Oxidative-Stress Responsive 1 (OXSR1))

Alternative Name: OXSR1 (OXSR1 Products)

Synonyms: OSR1 antibody, C20orf111 antibody, HSPC207 antibody, Osr1 antibody, Perit1 antibody, dJ1183I21.1 antibody, zgc:55494 antibody, zgc:77321 antibody, OXSR1 antibody, 2210022N24Rik antibody, 2810422B09Rik antibody, AI462649 antibody, AW209236 antibody, mKIAA1101 antibody, odd1 antibody, osr1 antibody, wu:fb77f12 antibody, zgc:165661 antibody, oxidative stress responsive 1 antibody, oxidative stress responsive serine rich 1 antibody, oxidative stress responsive 1b antibody, serine/threonine-protein kinase OSR1 antibody, odd-skipped related transciption factor 1 antibody, oxidative-stress responsive 1 antibody, oxidative stress responsive 1a antibody, OXSR1 antibody, OSER1 antibody, oxsr1b antibody, CpipJ_CPIJ015177 antibody, Tsp_00299 antibody, OSR1 antibody, Oxsr1 antibody, LOC106505565 antibody, oxsr1 antibody, oxsr1a antibody

Background:

Synonyms: KIAA1101, OSR 1, OSR1, Oxidative stress responsive 1, Oxidative stress responsive 1 protein, OXSR 1, Serine/threonine protein kinase OSR1.

Background: OXSR1 is a serine/threonine kinase which regulates downstream kinases in response to environmental stress such as osmotic stresses, notably sorbitol and, to a lesser extent, NaCl. OXSR1 phosphorylated thr84 within the N-terminal regulatory domain of PAK1. Replacement of thr84 with gln reduced activation of PAK1 by an active form of the small G protein CDC42, suggesting that phosphorylation by OXSR1 modulates the G protein sensitivity of PAK. OXSR1 interacts with chloride channel proteins SLC12A6 isoform 2, SLC12A1 and SLC12A2 but not with SLC12A4 and SLC12A7, possibly establishing sensor/signaling modules that initiate the cellular response to environmental stress. Binds to and phosphorylates RELL1, RELL2 AND RELT. OXSR1 may have a role in regulating the actin cytoskeleton.

Gene ID: 9943

Pathways: Tube Formation