TANK antibody (AA 151-260) (Biotin)

Catalog No. ABIN685359

This anti-TANK antibody is a Rabbit Polyclonal antibody detecting TANK in ELISA, IHC (p), IHC (fro). Suitable for Human.

Quick Overview for TANK antibody (AA 151-260) (Biotin) (ABIN685359)

Target: TANK (TRAF Family Member-Associated NFKB Activator (TANK))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TANK antibody is conjugated to Biotin

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-TANK Antibody (Biotin)

Binding Specificity: AA 151-260

Predicted Reactivity: Human,Mouse,Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human TANK

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for TANK

Target: TANK (TRAF Family Member-Associated NFKB Activator (TANK))

Alternative Name: TANK

Background:

Synonyms: I TRAF, ITRAF, TRAF family member associated NF KAPPA B activator, TRAF family member associated NFKB activator, TRAF interacting protein, TRAF interacting protein TANK isoform a, I-TRAF, Tank, TANK_HUMAN, TRAF family member-associated NF-kappa-B activator, TRAF-interacting protein, TRAF interacting protein TANK isoform b, TRAF2.

Background: TANK was initially identified as a novel TRAF-interacting protein that regulated TRAF-mediated signal transduction. Specifically, ligand binding by surface receptors in the tumor necrosis factor (TNF) receptor and Toll/interleukin-1 (IL-1) receptor families lead to the formation of a TRAF/TANK complex that mediates the activation of the transcription factor NF-kappaB. TANK is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm. For example, this protein can block TRAF2 binding to LMP1, the Epstein Barr virus transforming protein, and inhibit LMP1-mediated NF kappa B activation.

Gene ID: 10010

Pathways: p53 Signaling, TLR Signaling, Activation of Innate immune Response