AMPD3 antibody
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- Target See all AMPD3 Antibodies
- AMPD3 (Adenosine Monophosphate Deaminase 3 (AMPD3))
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This AMPD3 antibody is un-conjugated
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Application
- Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
- Specificity
- It recognizes a protein of ~90 kDa, which is identified as Adenosine Monophosphate Deaminase, isoform E (AMPD3). It has 767 amino acids and is assigned an EC 3.5.4.6. It is a highly regulated enzyme that catalyzes the hydrolytic deamination of adenosine monophosphate to inosine monophosphate, a branch point in the adenylate catabolic pathway. AMPD3 gene encodes the erythrocyte (E) isoforms, whereas other family members encode isoforms that predominate in muscle (M) and liver (L) cells. This MAb shows reactivity with cells of the erythroid lineage at all stages of maturation in the peripheral blood, bone marrow, and fetal liver. Non-erythroid lineages are negative by flow cytometry. This MAb is useful in the diagnosis of erythroleukemia, identification of bone marrow erythroid precursors, gating erythroid nucleated precursor cells from malignant cells in bone marrow specimens.
- Cross-Reactivity (Details)
- Human.
- Purification
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- Immunogen
- Recombinant full-length human AMDP3 protein
- Clone
- AMPD3-901
- Isotype
- IgG2b kappa
- Top Product
- Discover our top product AMPD3 Primary Antibody
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- Application Notes
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Known_Application: Immunohistochemistry (Formalin-fixed) (2-4 μg/mL for 30 minutes at RT) (Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.
Positive_Control: RBC. Fetal liver, Spleen or Placenta.
- Restrictions
- For Research Use only
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- Concentration
- 1.0 mg/mL
- Buffer
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
- Preservative
- Azide free
- Storage
- -20 °C,-80 °C
- Storage Comment
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- Expiry Date
- 24 months
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- Target
- AMPD3 (Adenosine Monophosphate Deaminase 3 (AMPD3))
- Alternative Name
- AMPD3 (AMPD3 Products)
- Synonyms
- ampd3 antibody, fi25h10 antibody, wu:fi25h10 antibody, zgc:55390 antibody, MGC108215 antibody, adenosine monophosphate deaminase 3 antibody, adenosine monophosphate deaminase 3b antibody, AMP deaminase 3 antibody, AMPD3 antibody, ampd3b antibody, PTRG_08116 antibody, ampd3 antibody, Ampd3 antibody
- Background
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Adenosine monophosphate deaminase (isoform E), AMP aminohydrolase, AMP deaminase 3, AMP deaminase isoform E, Ampd3, Erythrocyte AMP deaminase, Erythrocyte specific AMP deaminase, Erythrocyte specific protein, Erythrocyte type AMP deaminase, Myoadenylate deaminase,AMP Deaminase, Isoform E (AMPD3) (Erythroid Marker)
Cellular localisation: Cell Surface - Molecular Weight
- ~90kDa
- Gene ID
- 272, 501890
- UniProt
- Q01432
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