C1QA antibody (AA 104-237)
-
- Target See all C1QA Antibodies
- C1QA (Complement Component 1, Q Subcomponent, A Chain (C1QA))
-
Binding Specificity
- AA 104-237
-
Reactivity
- Human
-
Host
- Mouse
-
Clonality
- Monoclonal
-
Conjugate
- This C1QA antibody is un-conjugated
-
Application
- Western Blotting (WB), Immunohistochemistry (IHC), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
- Specificity
- C1q, a subcomponent of the classical complement pathway, is composed of nine subunits that mediate classical complement activation and thereby play an important role in the immune response. Six of these subunits are disulfide-linked dimers of chains A and B, while three of these subunits, designated C1q-A through C1q-C, are disulfide-linked dimers of chain C. Each chain contains an N-terminal collagen-like region and a C-terminal C1q globular domain. The presence of receptors for C1q on effector cells modulates its activity, which may be antibody-dependent or independent. Macrophages are the primary source of C1q, while anti-inflammatory drugs as well as cytokines differentially regulate expression of the mRNA as well as the protein. C1q deficiency is associated with lupus erythematosus and glomerulonephritis.
- Cross-Reactivity (Details)
- Human.
- Purification
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- Immunogen
- Recombinant fragment (around aa 104-237) of human C1QA protein (exact sequence is proprietary)
- Clone
- C1QA-2953
- Isotype
- IgG2b kappa
- Top Product
- Discover our top product C1QA Primary Antibody
-
-
- Application Notes
-
Known_Application: Western Blot (1-2 μg/mL),Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.
Positive_Control: Human liver or kidney tissue (IHC). PC-3 cell lysate (WB).
- Restrictions
- For Research Use only
-
- Concentration
- 1.0 mg/mL
- Buffer
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
- Preservative
- Azide free
- Storage
- -20 °C,-80 °C
- Storage Comment
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- Expiry Date
- 24 months
-
- Target
- C1QA (Complement Component 1, Q Subcomponent, A Chain (C1QA))
- Alternative Name
- C1QA (C1QA Products)
- Synonyms
- zgc:109903 antibody, C1QA antibody, AI255395 antibody, C1q antibody, complement C1q A chain antibody, complement component 1, q subcomponent, A chain antibody, complement component 1, q subcomponent, alpha polypeptide antibody, C1QA antibody, c1qa antibody, C1qa antibody
- Background
-
Complement C1q subcomponent subunit A, Complement component 1 q subcomponent alpha polypeptide,C1QA / Complement C1q A-Chain
Cellular localisation: Secreted - Molecular Weight
- 29kDa
- Gene ID
- 712, 632379
- UniProt
- P02745
- Pathways
- Complement System
-