C1QB antibody (AA 41-188)

Catalog No. ABIN6936541

Product Details anti-C1QB Antibody

Target: C1QB (Complement Component 1, Q Subcomponent, B Chain (C1QB))

Binding Specificity: AA 41-188

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This C1QB antibody is un-conjugated

Application: Immunohistochemistry (IHC), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Specificity: C1q, a subcomponent of the classical complement pathway, is composed of nine subunits that mediate classical complement activation and thereby play an important role in the immune response. Six of these subunits are disulfide-linked dimers of chains A and B, while three of these subunits, designated C1q-A through C1q-C, are disulfide-linked dimers of chain C. Each chain contains an N-terminal collagen-like region and a C-terminal C1q globular domain. The presence of receptors for C1q on effector cells modulates its activity, which may be antibody-dependent or independent. Macrophages are the primary source of C1q, while anti-inflammatory drugs as well as cytokines differentially regulate expression of the mRNA as well as the protein. C1q deficiency is associated with lupus erythematosus and glomerulonephritis.

Cross-Reactivity (Details): Human.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: Recombinant fragment (around aa 41-188) of human C1QB protein (exact sequence is proprietary)

Clone: C1QB-2961

Isotype: IgG1 kappa

Application Details

Application Notes:

Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

Positive_Control: Human liver, kidney or brain tissue (IHC).

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Expiry Date: 24 months

Target Details for C1QB

Target: C1QB (Complement Component 1, Q Subcomponent, B Chain (C1QB))

Alternative Name: C1QB (C1QB Products)

Synonyms: complement C1q B chain antibody, complement component 1, q subcomponent, beta polypeptide antibody, C1QB antibody, C1qb antibody

Background: C1QB, Complement component 1 q subcomponent B chain, Complement component C1q B chain,C1QB / Complement C1q B-Chain
Cellular localisation: Cytoplasmic and Cell Surface

Molecular Weight: 26-29kDa

Gene ID: 713, 8986

UniProt: P02746

Pathways: Complement System