CGB antibody
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- Target See all CGB Antibodies
- CGB (Chorionic Gonadotropin, beta Polypeptide (CGB))
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This CGB antibody is un-conjugated
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Application
- Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
- Specificity
- This MAb reacts with a protein of 22 kDa, identified as beta sub-unit of HCG. It does not cross react with the alpha sub-unit. HCG is a glycoprotein, which is secreted in large quantities by normal trophoblasts. It is present only in trace amounts in non-pregnant urine and sera but rises sharply during pregnancy. HCG is composed of two non-identical, non-covalently linked polypeptide chains designated as the subunit is identical to that of thyroid stimulating hormone (TSH) follicle stimulating hormone (FSH), and luteinizing hormone (LH). hCG MAb detects cells and tumors of trophoblastic origin such as choriocarcinoma. Large cell carcinoma and adenocarcinoma of the lung demonstrate anti-hCG positivity in 90 % and 60 % of cases respectively. 20 % of lung squamous cell carcinomas are positive. hCG expression by non-trophoblastic tumors may indicate aggressive behavior.
- Cross-Reactivity (Details)
- Human.
- Purification
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- Immunogen
- Recombinant full-length hCG beta protein
- Clone
- HCGb-54
- Isotype
- IgG1 kappa
- Top Product
- Discover our top product CGB Primary Antibody
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- Application Notes
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Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL) (Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.
Positive_Control: JAR or TT cells. Placenta.
- Restrictions
- For Research Use only
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- Concentration
- 1.0 mg/mL
- Buffer
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
- Preservative
- Azide free
- Storage
- -20 °C,-80 °C
- Storage Comment
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- Expiry Date
- 24 months
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- Target
- CGB (Chorionic Gonadotropin, beta Polypeptide (CGB))
- Alternative Name
- CGB (CGB Products)
- Synonyms
- CGB antibody, CGB3 antibody, CGB5 antibody, CGB7 antibody, CGB8 antibody, hCGB antibody, CG-beta antibody, chorionic gonadotropin, beta polypeptide antibody, chorionic gonadotropin beta subunit 3 antibody, CGB antibody, CGB3 antibody
- Background
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CG-beta, CGB3, CGB5, CGB7, CGB8, Choriogonadotropin Subunit beta, hCGB,HCG-beta (Pregnancy & Choriocarcinoma Marker)
Cellular localisation: Cytoplasmic, secreted - Molecular Weight
- 22kDa
- Gene ID
- 1082, 172944
- UniProt
- P01233
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