DPP4 antibody

Catalog No. ABIN6937102

This anti-DPP4 antibody is a Mouse Monoclonal antibody detecting DPP4 in FACS, IHC (fro) and IF. Suitable for Human.

Quick Overview for DPP4 antibody (ABIN6937102)

Target: DPP4 (Dipeptidyl-Peptidase 4 (DPP4))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This DPP4 antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF)

Clone: 202-36

Product Details anti-DPP4 Antibody

Specificity: Recognizes a glycoprotein of 110 kDa, identified as CD26 (Workshop VI, Code: N-L039). It is an atypical serine protease belonging to the prolyl oligopeptidase family. It is expressed on lymphocyte cells and is upregulated during T-cell activation. CD26 is also expressed on activated B cells and natural killer cells and abundantly on epithelia. CD26 is implicated in a variety of biological functions including T-cell activation, cell adhesion with extracellular matrix such as fibronectin or collagens, and in HIV infection. Cross-linking of CD26 using this antibody dramatically enhances the anti-CD3-induced IL-2 production. In Western blotting, this MAb reacts with only glycosylated CD26, but not with the deglycosylated form. It does not prevent ADA binding to CD26.

No Cross-Reactivity: Pig (Porcine), Sheep (Ovine)

Cross-Reactivity (Details): Human. Rat. Does not react with Pig or Sheep.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: Human T cell clone

Isotype: IgG2b kappa

Application Details

Application Notes:

Known_Application: Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), Immunohistochemistry (Frozen Only) (1-2 μg/mL for 30 minutes at RT) Optimal dilution for a specific application should be determined.

Positive_Control: YT, HEP-G2 cells and lymphocytes. Lymph nodes and tonsils.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Expiry Date: 24 months

Target Details for DPP4

Target: DPP4 (Dipeptidyl-Peptidase 4 (DPP4))

Alternative Name: DPP4

Background: ADA-binding protein (ADABP), Adenosine deaminase complexing protein 2 (ADCP-2), Dipeptidyl peptidase 4, Dipeptidyl peptidase 4 soluble form, Dipeptidyl peptidase IV membrane form, Dipeptidyl peptidase IV soluble form, Dipeptidyl peptidase, intestinal, Dipeptidylpeptidase 4, Dipeptidylpeptidase IV, DPP4, DPPIV, Intestinal dipeptidyl peptidase, T-cell activation antigen CD26, TP103,CD26 (DPP IV / ADA-Binding Protein)
Cellular localisation: Cell Surface

Molecular Weight: 110kDa

Gene ID: 1803, 368912

UniProt: P27487

Pathways: Peptide Hormone Metabolism, Regulation of Leukocyte Mediated Immunity