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STAR antibody (AA 39-108)

STAR Reactivity: Human IHC (f) Host: Mouse Monoclonal STAR-2154 unconjugated
Catalog No. ABIN6938458
  • Target See all STAR Antibodies
    STAR (Steroidogenic Acute Regulatory Protein (STAR))
    Binding Specificity
    • 15
    • 12
    • 8
    • 7
    • 7
    • 6
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 39-108
    Reactivity
    • 64
    • 20
    • 19
    • 1
    • 1
    • 1
    Human
    Host
    • 59
    • 5
    Mouse
    Clonality
    • 56
    • 8
    Monoclonal
    Conjugate
    • 28
    • 7
    • 6
    • 5
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This STAR antibody is un-conjugated
    Application
    • 44
    • 26
    • 14
    • 14
    • 11
    • 6
    • 5
    • 5
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
    Specificity
    Steroidogenic Acute Regulatory Protein (STAR) controls the rate-limiting step of steroidegenesis by translocating cholesterol from the outer mitochondrial membrane to the inner membrane where it is later cleaved to pregnenolone.It is primarily present in steroid-producing cells, including Leydig cells in the testis, theca cells and luteal cells in the ovary and adrenal cells in the adrenal cortex. Due to low levels of pregnenolone, seminomas and Leydig cell tumors display no specific STAR staining. Therefore, STAR antibody may assist in differentiating sex cord stromal tumors (SCST), seminomas and embryonal carcinomas.
    Cross-Reactivity (Details)
    Human.
    Purification
    1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
    Immunogen
    Recombinant fragment (around aa 39-108) of human STAR protein (exact sequence is proprietary)
    Clone
    STAR-2154
    Isotype
    IgG1 kappa
    Top Product
    Discover our top product STAR Primary Antibody
  • Application Notes

    Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 min at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.

    Positive_Control: K-562 cells. Adrenal or Testicular Carcinoma.

    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    Prepared in 10 mM PBS, WITHOUT BSA and Azide.
    Preservative
    Azide free
    Storage
    -20 °C,-80 °C
    Storage Comment
    Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
    Expiry Date
    24 months
  • Target
    STAR (Steroidogenic Acute Regulatory Protein (STAR))
    Alternative Name
    STAR (STAR Products)
    Synonyms
    STARD1 antibody, AV363654 antibody, D8Ertd419e antibody, star antibody, LOC100219165 antibody, StARD1 antibody, steroidogenic acute regulatory protein antibody, steroidogenic acute regulatory protein L homeolog antibody, STAR antibody, Star antibody, star antibody, star.L antibody
    Background
    Cholesterol trafficker, Luteinizing hormone induced protein, Mitochondrial steroid acute regulatory protein, StAR, StAR related lipid transfer (START) domain containing 1, StARD1, START domain-containing protein 1, Steroid acute regulatory protein, Steroidogenic acute regulator (STAR), Steroidogenic acute regulatory protein mitochondrial,StAR (Steroidogenic Acute Regulator) (Leydig Cell Marker)
    Cellular localisation: Cytoplasmic (Mitochondria)
    Molecular Weight
    30kDa
    Gene ID
    6770, 521535
    UniProt
    P49675
    Pathways
    Metabolism of Steroid Hormones and Vitamin D, Response to Growth Hormone Stimulus, C21-Steroid Hormone Metabolic Process, Cellular Response to Molecule of Bacterial Origin, Carbohydrate Homeostasis
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