TLR4 antibody

Catalog No. ABIN6938587

The Mouse Monoclonal anti-TLR4 antibody (Clone TLR4-230) (ABIN6938587) specifically detects TLR4 in Func. The antibody is reactive with Human, Rat, Dog, Pig, Guinea Pig and Monkey samples.

Quick Overview for TLR4 antibody (ABIN6938587)

Target: TLR4 (Toll-Like Receptor 4 (TLR4))

Reactivity: Human, Rat, Dog, Pig, Guinea Pig, Monkey

Host: Mouse

Clonality: Monoclonal

Conjugate: This TLR4 antibody is un-conjugated

Application: Functional Studies (Func)

Clone: TLR4-230

Product Details anti-TLR4 Antibody

Purpose: CD284 (Toll-Like Receptor 4) Antibody

Specificity: This MAb reacts with human Toll-like receptor 2 (TLR4). It is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene.

Cross-Reactivity (Details): Human. Monkey. Pig. Dog. Rat. Guinea Pig.

Purification: 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant full-length human TLR4 protein

Isotype: IgG2a, kappa

Application Details

Application Notes:

Known_Application: Functional Studies (Order Ab without Azide), Optimal dilution for a specific application should be determined.

Positive_Control: HeLa, PC12, human peripheral blood cells. Dendritic cells, macrophage and monocytes in tonsil, placenta and adrenal.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for TLR4

Target: TLR4 (Toll-Like Receptor 4 (TLR4))

Alternative Name: TLR4

Background:

ARMD10, CD284, hToll, TLR4, TOLL, Toll Endotoxin Hyporesponsiveness, Toll-like receptor 4

HeLa, human peripheral blood cells. Dendritic cells, macrophage and monocytes in tonsil, placenta and adrenal., PC12

Molecular Weight: 95-120kDa

Gene ID: 7099, 174312

UniProt: O00206

Pathways: TLR Signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades, Inflammasome, S100 Proteins