TNFRSF13C antibody

Catalog No. ABIN6939146

The Mouse Monoclonal anti-TNFRSF13C antibody is suitable to detect TNFRSF13C in samples from Human. It has been validated for IHC and StM.

Quick Overview for TNFRSF13C antibody (ABIN6939146)

Target: TNFRSF13C (Tumor Necrosis Factor Receptor Superfamily, Member 13C (TNFRSF13C))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TNFRSF13C antibody is un-conjugated

Application: Immunohistochemistry (IHC), Staining Methods (StM)

Clone: BAFFR-1557

Product Details anti-TNFRSF13C Antibody

Immunogen: Recombinant full-length human CD268 protein

Isotype: IgG1 kappa

Application Details

Application Notes:

Positive Control: Raji cells. Tonsil and lymph node.

Known Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for TNFRSF13C

Target: TNFRSF13C (Tumor Necrosis Factor Receptor Superfamily, Member 13C (TNFRSF13C))

Alternative Name: TNFRSF13C

Background: Defects in TNFRSF13C are the cause of immunodeficiency common variable type 4 (CVID4) [MIM:613494], also called antibody deficiency due to BAFFR defect. CVID4 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins, the numbers of circulating B cells is usually in the normal range, but can be low.

Molecular Weight: 19kDa (Monomer), 40kDa (Dimer)

Gene ID: 115650

UniProt: Q96RJ3

Pathways: NF-kappaB Signaling