TNFRSF13C antibody (AA 7-71)

Catalog No. ABIN7092943

The Rabbit Monoclonal anti-TNFRSF13C antibody is suitable to detect TNFRSF13C in samples from Human. It has been validated for FACS, IHC and ELISA.

Quick Overview for TNFRSF13C antibody (AA 7-71) (ABIN7092943)

Target: TNFRSF13C (Tumor Necrosis Factor Receptor Superfamily, Member 13C (TNFRSF13C))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This TNFRSF13C antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunohistochemistry (IHC), ELISA

Clone: DM143

Product Details anti-TNFRSF13C Antibody

Binding Specificity: AA 7-71

Purpose: Anti-BAFF-R antibody(DM143), Rabbit mAb

Purification: Purified from cell culture supernatant by affinity chromatography

Immunogen: Recombinant human BAFFR(Ser7-Ala71) (ABIN6961114) produced by using human HEK293 cells

Isotype: IgG

Application Details

Application Notes: ELISA 1:5000-10000, Flow Cyt 1:100, IHC 1:100

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please see Certificate of Analysis for specific instructions of reconstitution.

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Expiry Date: 12 months

Target Details for TNFRSF13C

Target: TNFRSF13C (Tumor Necrosis Factor Receptor Superfamily, Member 13C (TNFRSF13C))

Alternative Name: BAFF-R

Background: Synonyms:BAFFR,TNFRSF13C,BAFF-R,BROMIX,CD268,CVID4,prolixin
Description:B cell-activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of Baff in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular cysteine-rich domain. It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival.

Molecular Weight: 18.8KDa

UniProt: Q96RJ3

Pathways: NF-kappaB Signaling